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Background: Cerebral embolic protection devices (CEPDs) have been developed to decrease embolic brain injury and stroke during transcatheter aortic valve replacement (TAVR). Simplifying vascular access for a CEPD may increase procedural efficiency and safety FIRST-IN-HUMAN/EARLY REPORTS SUMMARY: This is the first published report of the use of the novel EnCompass F filter, which consists of a cylindrical nitinol frame and electrospun filter. Complete cerebral embolic protection during TAVR is possible through single femoral arterial access.
Discussion: Cerebral protection was feasible and safe without device-related complications, clinical stroke, or other neurologic events. Postprocedural diffusion-weighted magnetic resonance imaging revealed only 1 very small, clinically insignificant new brain lesion.
Novelty: This presents the first successful use of a CEPD in TAVR through access by a single femoral artery.
Take-home Message: The use of the novel EnCompass F filter was feasible to provide complete cerebral embolic protection in TAVR using a single access.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198642 | PMC |
http://dx.doi.org/10.1016/j.jaccas.2025.103768 | DOI Listing |
Cardiovasc Intervent Radiol
September 2025
Neuroradiologische Klinik, Kopf- Und Neurozentrum, Klinikum Stuttgart, Kriegsbergstraße 60, 70174, Stuttgart, Germany.
J Am Coll Cardiol
September 2025
Acute Multidisciplinary Imaging and Interventional Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom; Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom. Electroni
Cardiol Rev
September 2025
Departments of Cardiology and Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY.
Arteriovenous malformations (AVMs) are abnormal connections between cerebral arteries and veins that lack an intervening capillary bed. Brain AVMs affect approximately 0.1% of the population and are diagnosed in 1.
View Article and Find Full Text PDFActa Physiol (Oxf)
October 2025
Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Background: The cerebral circulation is continuously challenged by intravascular micrometer-sized particles that become trapped microvascular-emboli. These particles may include micro-thrombi, stiffened erythrocytes, and leukocytes, while also fat particles, air, and microplastics may cause microvascular embolism.
Review Scope: In this narrative review, we discuss these embolization processes and their acute and chronic consequences.
Exp Ther Med
November 2025
Department of Neurosurgery, Nanchong Shenxin Hospital, Nanchong, Sichuan 637003, P.R. China.
Wide-necked anterior communicating artery (ACoA) aneurysms pose challenges for endovascular coiling due to the risk of coil protrusion. This case report describes a new endovascular technique for managing ruptured wide-necked ACoA aneurysms, addressing the risk of coil protrusion during embolization. This method employs a combined microcatheter and guidewire-assisted embolization method, enabling coil deployment without needing adjunctive devices such as stents or balloons.
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