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Gas composition and pressure in the hypopharynx during high-flow oxygen therapy through a nasal cannula in healthy volunteers with different breathing patterns.
BMC Anesthesiol
August 2025
Pulmonology Department, Sechenov First Moscow State Medical University (Sechenov University), 8/2, Trubetskaya Str, Moscow, 119991, Russia.
Background: High-flow nasal cannula is widespread in patients with hypoxemic and hypercapnic respiratory failure, but physiological data concerning influence of the combination of breathing pattern, preset flow rate (PFR), and inspiratory oxygen fraction (FO) on end-expiratory pressure (EEP), capnogram, oxygram, and exhaled tidal volume (VTe) remains insufficient.
Methods: The study included 20 healthy subjects with 12 combinations of PFR (30-60-80 L/min) and FO (40-60-80-100%) multiplied by 4 breathing patterns: mouth closed (CM), mouth open (OM), and combination of the CM and OM with hyperpnea (HCM and HOM). Pressure, capnogram, oxygram were measured from hypopharyngeal catheter, VTe, and subject's comfort were assessed.
Expression of immunophenotypic markers in blood mononuclear cells of patients with advanced head and neck squamous cells carcinoma.
Acta Cir Bras
August 2025
Universidade Federal de Minas Gerais - Faculty of Medicine - Department of Surgery - Belo Horizonte (MG), Brazil.
Purpose: To evaluate peripheral blood mononuclear cells (PBMCs) from patients with advanced head and neck squamous cell carcinoma (HNSCC) in comparison with healthy volunteers, as they can be potential biomarkers.
Methods: Immunophenotyping was performed using flow cytometry of blood mononuclear cells from two groups of adult men: group 1 (n = 14), diagnosed with HNSCC (mouth, larynx, and hypopharynx); and group 2 (n = 14), volunteers, healthy, and without the use of drugs. The cell groups studied were T lymphocytes (CD3, CD4, CD8, CD56 and CD69), B lymphocytes (CD19, CD69), neutrophils (CD11a, CD16, CD66b, HLA-DR), and monocytes (CD14, CD86).
In Reference to Bariatric Surgery Lowers Incidence of Chronic Rhinosinusitis and Functional Endoscopic Sinus Surgery.
Laryngoscope
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Department of Surgery, Faculty of Medicine, University of Mons (UMons), Mons, Belgium.
Laryngopharyngeal dysesthesia as a possible clinical manifestation of a cytokine release reaction due to oxaliplatin.
J Oncol Pharm Pract
July 2025
Allergy Department, Castellon University General Hospital, Castellón, Spain.
IntroductionLaryngopharyngeal dysesthesia is considered an acute peripheral neuropathy secondary to oxaliplatin neurotoxicity.Case reportWe report a case of laryngopharyngeal dysesthesia that developed in a patient with colon adenocarcinoma after receiving her third cycle of oxaliplatin.Management & outcomeShe was treated with antihistamines, steroids, oxygen, and adrenaline and referred to the allergy department for investigation of a hypersensitivity reaction to the drug.
View Article and Find Full Text PDF[Laryngopharyngeal reflux disease-update 2025 : Revision taking into consideration the European CEORL-HNS guideline].
HNO
August 2025
Klinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20251, Hamburg, Deutschland.
Laryngopharyngeal reflux disease (LPRD), a common condition with a variety of symptoms, often occurs without heartburn. One of the main causes appears to be the pepsin effect. Systematic recording of symptoms and findings confirms the suspected diagnosis.
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