98%
921
2 minutes
20
Memristors have emerged as a key building block for artificial neural networks (ANNs), offering energy efficiency and high scalability for hardware-based synaptic weight updates. As device miniaturization is crucial for enhancing memristor performance, hexagonal boron nitride (h-BN) stands out as a promising resistive switching medium due to its excellent insulating characteristics even at an atomically thin scale. However, conventional h-BN memristors suffer from abrupt switching behavior by uncontrollable filament formation, limiting their potential for ANN applications. Here, h-BN-based memristors exhibiting linear and symmetric analog switching by leveraging multiple nano-filament confinement is presented. The geometric confinement between suspended h-BN films and the apexes of GaN nano-cones facilitates analog switching behavior, reducing cycle-to-cycle variation and ensuring stable consecutive operations. Electrical analyses reveal that analog switching behavior originates from the controlled formation of multiple nano-filaments within the confined geometry. ANNs implemented with these nano-filaments confined to h-BN memristors exhibit highly linear and symmetric synaptic weight updates, enabling precise training with minimal accuracy degradation. This work establishes multiple nano-filament confinement as a universal design strategy for achieving reliable and linear analog switching in memristors, paving the way for advanced neuromorphic computing.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366253 | PMC |
http://dx.doi.org/10.1002/smll.202504507 | DOI Listing |
Front Med (Lausanne)
August 2025
The First Department of Liver Disease Center, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Introduction: Low-level viremia (LLV) is associated with the progression of liver fibrosis and a high risk of hepatocellular carcinoma in patients with chronic hepatitis B (CHB). The present study aimed to compare the efficacy between nucleos(t)ide analogs (NAs) therapy and combination therapy of NAs and pegylated interferon-α (pegIFN-α) in entecavir (ETV)-treated CHB patients with LLV.
Methods: This was a retrospective cohort study.
J Colloid Interface Sci
September 2025
School of Electronic Information & Artificial Intelligence, Shaanxi University of Science and Technology, Xi'an 710021, China.
The integration of information memory and computing enabled by nonvolatile memristive device has been widely acknowledged as a critical solution to circumvent the von Neumann architecture limitations. Herein, the Au/NiO/CaBiTiO/FTO (CBTi/NiO) heterojunction based memristor with varying film thicknesses are demonstrated on FTO/glass substrates, and the CBTi/NiO-4 sample shows the optimal memristor characteristics with 5 × 10 stable switching cycles and 10-s resistance state retention. The electrical conduction in the low-resistance state is dominated by Ohmic behavior, while the high-resistance state exhibited characteristics consistent with the space-charge-limited conduction (SCLC) model.
View Article and Find Full Text PDFBMC Infect Dis
September 2025
Department of Infectious Diseases, Center of Clinical Research and Disruption of Infectious Diseases (CREDID), Copenhagen University Hospital - Amager and Hvidovre, Kettegaard Allé 30, Hvidovre, 2650, Denmark.
Background: Antiretroviral therapy (ART) in people with HIV (PWH) can lead to weight gain, but the effects of nucleoside reverse transcriptase inhibitors such as abacavir (ABC) are not well understood. In this study, we investigated whether discontinuing ABC would mitigate weight changes and metabolic complications in PWH.
Methods: In a randomized controlled trial including PWH on dolutegravir, ABC, and lamivudine (DTG/ABC/3TC), participants were randomized 2:1 to either switch to DTG/3TC or continue DTG/ABC/3TC.
Chem Sci
August 2025
Department of Chemistry, Dartmouth College Hanover New Hampshire 03755 USA
Azo-BF complexes are visible and near-infrared (NIR) light-activated photoswitches showcasing versatility in applications ranging from energy storage to three-dimensional displays. While highly appealing as molecular switches, factors that affect their photophysical properties and solution-state reactivity still need to be teased out. In this paper, we present the synthesis and characterization of two azo-BF analogues (1 and 2), each modified with structurally distinct dimethylamine-substituted naphthalene moieties.
View Article and Find Full Text PDFChem Sci
August 2025
Department of Chemistry and Materials Science, Shinshu University 3-15-1, Tokida Ueda Nagano 386-8567 Japan
Synthetic ion channels represent an emerging class of therapeutics. However, most synthetic ion channels are derived from small molecules, whose rapid clearance from the body limits their therapeutic potential. Here, we report macromolecular ion transport systems based on amphiphilic polyether block copolymers.
View Article and Find Full Text PDF