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Unlabelled: A patient with ulcerated skin lesions of unknown etiology on his left leg underwent pacemaker implantation for atrioventricular block caused by cardiac sarcoidosis (CS). After initiation of corticosteroid for CS, his skin lesions improved. The lesions were diagnosed as pyoderma gangrenosum (PG) from the findings of a skin biopsy and the reaction to corticosteroid. PG causes skin necrosis associated with immune system disorders after slight stimulation. Although we worried about wound healing after pacemaker implantation, the wound healed well under the corticosteroid treatment. This is the first report of successful pacemaker implantation in a patient with both PG and CS.
Learning Objective: Conventional transvenous pacemakers can be implanted for pyoderma gangrenosum patients by early initiation of corticosteroid.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166934 | PMC |
http://dx.doi.org/10.1016/j.jccase.2025.02.005 | DOI Listing |
J Eur Acad Dermatol Venereol
September 2025
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
J Dermatolog Treat
December 2025
Department of Dermatology, Peking University Third Hospital, Beijing, China.
Aim: To evaluate the therapeutic efficacy and safety of the Janus kinase (JAK) inhibitor tofacitinib in the management of refractory perianal pyoderma gangrenosum (PG) under conditions of baseline immunosuppression and bone marrow suppression.
Methods: We present a 62-year-old male with a 4-month history of painful, progressive symmetrical perianal ulcerations diagnosed as PG, coexisting with condyloma acuminatum. The patient had a background of pure red cell aplasia and myasthenia gravis, and was undergoing chronic immunosuppressive therapy with prednisolone and tacrolimus.
Australas J Dermatol
September 2025
Concord Repatriation General Hospital, New South Wales, Australia.
J Am Acad Dermatol
September 2025
Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
J Surg Res
September 2025
Nationwide Children's Hospital, Abigail Wexner Research Institute, Columbus, Ohio; Department of Plastic and Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio; Pediatric Comprehensive Wound Program, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: Jenny.Barker
Introduction: Chronic wounds affect approximately 10.5 million individuals annually in the United States. Although recent studies have highlighted a surge in chronic wound cases among younger populations, the collective burden of pediatric chronic wounds remains understudied.
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