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http://dx.doi.org/10.1111/cea.70094 | DOI Listing |
Clin Exp Allergy
June 2025
Division of Allergy & Respiratory Medicine Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, South Korea.
Mod Rheumatol
September 2025
Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Objectives: The aim of this article is to investigate the prevalence of systemic lupus erythematosus (SLE) in Japan and explore its treatment regimens in different age groups.
Methods: We identified patients with SLE from the National Database of Health Insurance Claims of anonymized health insurance-related information; they had disease names associated with SLE and were treated with glucocorticoids, hydroxychloroquine, or immunosuppressants. These data were used to investigate disease prevalence and profiles in Japan.
PLoS Biol
November 2024
MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, United Kingdom.
Humans experience many influenza infections over their lives, resulting in complex and varied immunological histories. Although experimental and quantitative analyses have improved our understanding of the immunological processes defining an individual's antibody repertoire, how these within-host processes are linked to population-level influenza epidemiology in humans remains unclear. Here, we used a multilevel mathematical model to jointly infer antibody dynamics and individual-level lifetime influenza A/H3N2 infection histories for 1,130 individuals in Guangzhou, China, using 67,683 haemagglutination inhibition (HI) assay measurements against 20 A/H3N2 strains from repeat serum samples collected between 2009 and 2015.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2024
VEO Greater China and Intercontinental, GSK, Singapore, Singapore.
In Singapore, population aging and rising life expectancy are increasing herpes zoster (HZ) burden, which may be reduced by vaccination. The present study modeled the public health impact of HZ vaccination in Singapore using ZOster ecoNomic Analysis (ZONA) model adapted with Singapore-specific key model inputs, where available. Base case analysis was conducted in adults ≥ 50 years of age (YOA), exploring three vaccination strategies (no vaccination, recombinant zoster vaccine [RZV], zoster vaccine live [ZVL]) under mass vaccination setting (30% coverage).
View Article and Find Full Text PDFmedRxiv
April 2024
MRC Centre for Global Infectious Disease Analysis, Imperial College London.
Humans experience many influenza infections over their lives, resulting in complex and varied immunological histories. Although experimental and quantitative analyses have improved our understanding of the immunological processes defining an individual's antibody repertoire, how these within-host processes are linked to population-level influenza epidemiology remains unclear. Here, we used a multi-level mathematical model to jointly infer antibody dynamics and individual-level lifetime influenza A/H3N2 infection histories for 1,130 individuals in Guangzhou, China, using 67,683 haemagglutination inhibition (HI) assay measurements against 20 A/H3N2 strains from repeat serum samples collected between 2009 and 2015.
View Article and Find Full Text PDF