98%
921
2 minutes
20
Background: Malnutrition is a risk factor for poor surgical outcomes amongst the elderly. However, the association between malnutrition and outcomes in geriatric patients undergoing spine surgery has been understudied. The aim of this study was to assess associations between malnutrition and 30-day morbidity and mortality in geriatric patients undergoing spine surgery.
Methods: A retrospective cohort study was performed using the American College of Surgeons National Surgical Quality Improvement Program database. All geriatric patients (≥ 65 years old) were categorized by Geriatric Nutritional Risk Index (GNRI) score: Normal, Malnourished, and Severely Malnourished. Patient demographics, comorbidities, and adverse events (AEs) were assessed. Multivariable logistic regression analyses identified independent predictors of 30-day postoperative AEs, extended length of stay (LOS), non-routine discharge (NRD), unplanned readmission, and mortality.
Results: Of the 79,160 patients identified, 58,906 (74.4 %) had Normal nutritional status, 12,184 (15.4 %) were Malnourished, and 8070 (10.2 %) were Severely Malnourished. The Malnourished and Severely Malnourished cohorts had significantly increased proportion of AEs (p < 0.001) and a longer LOS (p < 0.001). The Malnourished and Severely Malnourished cohorts had significantly increased proportions of NRD (p < 0.001), unplanned readmissions (p < 0.001), and 30-day mortality (p < 0.001). On multivariable analysis, Malnourished and Severely Malnourished statuses, respectively, were independently associated with any AE (p < 0.001), extended LOS (p < 0.001), 30-day unplanned readmission (p < 0.001), NRD (p < 0.001), and 30-day mortality (p < 0.001).
Conclusion: Our study suggests that preoperative GNRI-defined malnutrition may increase the risk of adverse postoperative outcomes following spine surgery in geriatric patients.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.clineuro.2025.109000 | DOI Listing |
Diagn Progn Res
September 2025
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Hospital-acquired venous thromboembolism (HA-VTE) is a leading cause of morbidity and mortality among hospitalized adults. Numerous prognostic models have been developed to identify those patients with elevated risk of HA-VTE. None, however, has met the necessary criteria to guide clinical decision-making.
View Article and Find Full Text PDFNeurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University.
Intra-aneurysmal thrombus formation is crucial for the healing of endovascularly treated aneurysms. This study evaluated whether T1-weighted black blood imaging can monitor thrombus formation by examining the relationship between chronological signal intensity changes and aneurysm occlusion status after flow diverter stenting and coil embolization. We retrospectively analyzed 78 patients with 83 aneurysms (flow diverter stenting: 28, coil embolization: 55) who underwent T1-weighted black blood imaging at 1 week, 3 months, and 6 months post-treatment.
View Article and Find Full Text PDFJ Obes Metab Syndr
September 2025
Integrated Perioperative Geriatric Excellent Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Morbid obesity is a well-established risk factor for cardiovascular disease. Diastolic dysfunction, particularly in non-cardiac surgeries, has been associated with increased incidence of adverse cardiovascular events. This study aimed to evaluate the prevalence of diastolic dysfunction in morbidly obese patients undergoing bariatric surgery and to identify associated clinical risk factors using transesophageal echocardiography (TEE).
View Article and Find Full Text PDFClin Pharmacol Ther
September 2025
School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
This cross-sectional study aims to demonstrate the impact of China's 2015 review and approval reform on the delays in market entry for novel geriatric drugs, as well as the capability of domestic innovation in developing geriatric drugs. We analyzed the novel geriatric drugs approved by the US Food and Drug Administration (FDA) between 2005 and 2024 to assess the drug lags in China by using the EU and Japan as comparators. During this period, the FDA approved a total of 183 novel drugs targeting geriatric diseases, of which 109 were also approved by the NMPA.
View Article and Find Full Text PDFBone Jt Open
September 2025
School of Medicine, University of Nottingham, Nottingham, UK.
Aims: The number of hip fractures is increasing, with significant mortality and morbidity, particularly among frail and comorbid patients. Enhanced recovery after surgery (ERAS) pathways have proven effective in elective orthopaedics, but this has not been investigated in people with hip fractures. This study aimed to identify current perioperative practice and develop a cohesive ERAS pathway tailored for hip fracture patients, to standardize and optimize care.
View Article and Find Full Text PDF