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Background: Adverse childhood experiences (ACE or childhood trauma) include very stressful and potentially traumatic events linked to a higher risk of mental health challenges and chronic conditions. India has an opportunity to study the association between ACE exposure and internalizing symptoms (depression and anxiety). To evaluate the association between exposure to ACE and internalizing symptoms (depression and anxiety) at a wellness centre in India.
Methods And Material: This cross-sectional study studied a convenience sample of 909 individuals who self-assessed ACE exposure, depression (Major Depression Inventory: MDI), and anxiety levels (Generalized Anxiety Disorder: GAD-7). Logistic regression models evaluated the association between ACE and depression and anxiety levels.
Results: The results show a strong association between ACE levels and depression as well as anxiety. Individuals with medium (1-3 ACEs), high (4-6 ACEs), and very high (> =7 ACEs) exposure to childhood trauma are at 2-7 odds of having major depression and 1-3 odds of having anxiety. Moreover, both Gen Z and Gen Y are at a higher risk of depression and anxiety compared with Gen X.
Conclusions: The research extends the findings from global research on ACE and mental health (depression, anxiety) in India, highlighting the strong association. Future work should expand the samples across the geography to enhance the insights.
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http://dx.doi.org/10.4103/ijcm.ijcm_419_23 | DOI Listing |
J Appl Gerontol
September 2025
Department of Medical Psychology and Sociology, Faculty of Medicine, Institute of Theoretical Medicine, University of Augsburg, Germany.
Research on the relatives' well-being during the critical time point when their family member is hospitalized in an acute psychiatric hospital is still lacking. Therefore, we investigated psychological well-being, care-related burden, and communication challenges of 67 relatives of older patients with dementia (RPwD) versus 60 relatives of older patients with a psychiatric disorder (RPP) at the time of hospitalization. RPwD reported significantly higher levels of depression and care-related burden compared to RPP (there was a similar non-significant trend for anxiety).
View Article and Find Full Text PDFAm J Respir Cell Mol Biol
September 2025
University of Toronto, Interdepartmental Division of Critical Care Medicine, Toronto, Ontario, Canada.
Post-Intensive Care Syndrome (PICS) is a serious condition involving physical weakness, depression, and cognitive impairment that develop during or after an intensive care unit (ICU) stay, often resulting in long-term declines in quality of life. Patients with acute respiratory distress syndrome (ARDS) and severe COVID-19 are at particularly high risk, yet the molecular mechanisms underlying PICS remain poorly understood. Here, we identify impaired Apelin-APJ signaling as a potential contributor to PICS pathogenesis via disruption of inter-organ homeostasis.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, United States of America.
While the COVID-19 pandemic has significantly impacted mental health, limited information exists on the relationship between COVID-19 infection and mental health disorders in children and adolescents. This study explored the association between COVID-19 infection, infection severity, and the risk of depression and anxiety among school-aged youth. Data from the 2019-2021 Utah All Payers Claims Database (APCD) was used to identify children and adolescents (aged 6-15 years in 2019) covered by private insurance or Medicaid.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Health Sciences, University of York, York, United Kingdom.
Background: Previous studies have shown associations between specific limiting longstanding illnesses and mental health difficulties using cross-sectional studies in the UK. This study explored the association between having any limiting longstanding illness and serious psychological distress or of currently receiving treatment for depression or serious anxiety at age 17 years.
Methods: A secondary analysis of the UK Millennium Cohort Study was conducted.
J Vis Exp
August 2025
School of Life Sciences, Shanghai University; Division of Biology and Biological Engineering, California Institute of Technology;
The hypothalamus is an ancient brain region that regulates diverse aspects of physiology and behavior, including sleep and wakefulness, appetite, energy homeostasis, anxiety, depression, and social interaction. Specific neuronal populations in the hypothalamus exert their effects via the release of neurotransmitters and neuropeptides. Whole-cell patch-clamp recording is an indispensable approach for studying the roles of these factors in synaptic transmission and brain function.
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