Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Anxiety disorders are among the most common psychiatric conditions that significantly impair one's quality of life and place a significant burden on healthcare systems. Conventional treatments have certain restraints, such as potential side effects and limited efficacy. Τhe underlying pathophysiological mechanisms of anxiety are not fully understood. A comprehensive literature search was performed in MEDLINE and Scopus databases for original English-language articles published between January 2014 and December 2024. Study selection, data extraction, and screening were independently carried out by multiple investigators using predefined criteria. Our review aimed to help better comprehend the molecular basis of anxiety, focusing on the hypothalamic-pituitary-adrenal (HPA) axis, serotonergic signaling, and gamma-aminobutyric acid (GABA) neurotransmission. In addition, we addressed the role of epigenetics and pharmacogenomics in personalized treatment. Although novel anxiety treatments are promising, they are predominantly preclinical and highly heterogeneous, which poses a challenge to achieving reliable therapeutic efficacy. Our findings could potentially contribute to the development of new therapeutic interventions. Further research is warranted, especially in human subjects, with an aim to combine genetic and epigenetic profiles to refine treatment approaches and develop innovative therapeutics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12155146 | PMC |
| http://dx.doi.org/10.3390/ijms26115417 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice.
Am J Chin Med
September 2025
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Astragaloside IV (ASIV), the main active component of the traditional Chinese medicine HuangQi, exhibits ameliorating effects on myocardial fibrosis through unclear mechanisms. To investigate the effects of ASIV on Endothelial-to-mesenchymal transition (EndMT) in myocardial fibrosis, 10 ng/mL TGF-β1 was used to induce EndMT in human umbilical vein endothelial cells (HUVECs) and a 5 mg/kg/d subcutaneous injection of Isoproterenol (ISO) was used to induce myocardial fibrosis in mice . The drug affinity-responsive target stability (DARTS) was used to identify the target proteins of ASIV in endothelial cells.
View Article and Find Full Text PDFStructural analysis of the NifL-NifA complex reveals the molecular basis of anti-activation of nitrogen fixation gene expression in Azotobacter vinelandii.
FEBS J
September 2025
Department of Molecular Microbiology, John Innes Centre, Norwich, UK.
Understanding the molecular basis of regulated nitrogen (N) fixation is essential for engineering N-fixing bacteria that fulfill the demand of crop plants for fixed nitrogen, reducing our reliance on synthetic nitrogen fertilizers. In Azotobacter vinelandii and many other members of Proteobacteria, the two-component system comprising the anti-activator protein (NifL) and the Nif-specific transcriptional activator (NifA)controls the expression of nif genes, encoding the nitrogen fixation machinery. The NifL-NifA system evolved the ability to integrate several environmental cues, such as oxygen, nitrogen, and carbon availability.
View Article and Find Full Text PDFEnvironmental stressor-induced functional and expression dynamics of glutathione S-transferase genes in bees.
Pestic Biochem Physiol
November 2025
College of Life Sciences, Chongqing Normal University, Chongqing, China; Key Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing, China; Chongqing Key Laboratory of Vector Control and Utilization, Chongqing,
As key pollinators, bees are increasingly threatened by environmental stressors such as heavy metals, pesticides, and temperature fluctuations, which can cause oxidative stress and disrupt cellular homeostasis. Glutathione S-transferases (GSTs) play crucial roles in antioxidant defense and detoxification, yet systematic studies on bee GST families remain limited. Here, we conducted a genome-wide analysis of cytosolic GST genes in 13 bee species, identifying 146 genes in total.
View Article and Find Full Text PDFThe pleiotropic odorant binding protein CaspOBP12 involved in perception of Ceutorhynchus asper for plant volatiles and pesticides.
Pestic Biochem Physiol
November 2025
Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China; Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau of Ministry of Agriculture and Rural
The olfactory system of insects plays a vital role in their survival by enabling them to detect chemical cues and adapt to changing environments. The rape stem weevil, Ceutorhynchus asper, is a significant pest posing a challenge for rapeseed production due to its destructive feeding habit and increasing resistance to insecticides. So far, there's still limited knowledge about structure and function of odorant binding proteins (OBPs) in beetles like C.
View Article and Find Full Text PDFBmeIF4E2 promotes AcMNPV infection in the silkworm, Bombyx mori, by direct interaction.
Pestic Biochem Physiol
November 2025
Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China; Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Research Inst
The molecular mechanism of baculovirus infection is the basis of baculovirus wide application. Identifying and elucidating the functional genes of virus replication is the focus of research. Eukaryotic initiation factor 4E (eIF4E) is a key component of the translation initiation process to synthesize proteins required for replication.
View Article and Find Full Text PDF