The Light-Regulated Transcription Factor Promotes Flavonoids in .

Int J Mol Sci

Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, National Center for Traditional Chinese Medicine (TCM) Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.

Published: May 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Dunn is rich in flavonoids, which were previously demonstrated to respond to changing light conditions. In this study, through weighted gene co-expression network analysis (WGCNA), genes were screened as the potential regulator for these light-intensity-induced changes. One gene, , was chosen for in-depth research. Analysis showed that was an R2R3-type MYB transcription factor, regulated by light, and involved in controlling the light responses of . was then transiently overexpressed in flowers and stably overexpressed in Domin. overexpression promoted flavonoids (especially catechins) accumulation, and affected expressions of all the flavonoid biosynthetic pathway genes. In transient overexpression, was the only significantly decreased gene, while other 17 genes were significantly increased. In stable overexpression, nearly all genes were upregulated or at least unchanged. overexpression also might function in inhibiting anthocyanin and lignin biosynthesis. This study deepens our understanding of gene functions in regulating and enhancing flavonoids, and would be beneficial for designing high-valued in future.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12155114PMC
http://dx.doi.org/10.3390/ijms26115292DOI Listing

Publication Analysis

Top Keywords

transcription factor
8
light-regulated transcription
4
factor promotes
4
flavonoids
4
promotes flavonoids
4
flavonoids dunn
4
dunn rich
4
rich flavonoids
4
flavonoids demonstrated
4
demonstrated respond
4

Similar Publications

The OsbZIP35-COR1-OsTCP19 module modulates cell proliferation to regulate grain length and weight in rice.

Sci Adv

September 2025

Frontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization (MOE), Beijing Key Laboratory of Crop Genetic Improvement, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.

Grain size substantially influences rice quality and yield. In this study, we identified (), a quantitative trait locus encoding an F-box protein that enhances grain length by promoting cell proliferation. The transcription factor OsbZIP35 represses expression, while COR1 interacts with OsTCP19, leading to its degradation.

View Article and Find Full Text PDF

CD8HLA-DRCD27 T cells define a population of naturally occurring regulatory precursors in humans.

Sci Adv

September 2025

Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University, Beijing, China.

Regulatory T cells are essential for immune homeostasis. While CD4 T cells are well characterized, CD8 T cells remain less understood and are primarily observed in pathological or experimental contexts. Here, we identify a naturally occurring CD8 regulatory precursor T cell at the steady state, defined by a CD8HLA-DRCD27 phenotype and a transcriptome resembling CD4 T cells.

View Article and Find Full Text PDF

IFN-β, a type I interferon, has been used as a first-line therapy for patients with multiple sclerosis (MS) for more than 30 years; however, the cellular and molecular basis of its therapeutic efficacy remains unclear. Here, we first used experimental autoimmune encephalomyelitis (EAE), a mouse model for MS, to show that the therapeutic effects of IFN-β were associated with a down-regulation of microRNA-21 (miR-21) and pathogenic T17 (pT17) cells. In vitro experiments demonstrated that genetic knockout of miR-21 directly inhibited pathogenic T17 cell differentiation.

View Article and Find Full Text PDF

From Biological Mechanisms to Clinical Applications: A Review of Photobiomodulation in Dental Practice.

Photobiomodul Photomed Laser Surg

September 2025

Department of Oral and Maxillofacial Diagnostic Sciences, Dental College and Hospital, Taibah University, Medina, Saudi Arabia.

Photobiomodulation (PBM) therapy involves the use of low-dose, nonionizing light to reduce pain and inflammation, promote wound healing, and enhance tissue regeneration. PBM-based therapy of various dental conditions is associated with improved treatment outcomes. This study aims to critically review the literature to highlight the underlying molecular biological mechanisms and clinical applications of PBM in modern dental practice.

View Article and Find Full Text PDF

The p53 transcription factor family consists of the three members p53, p63, and p73. Both p63 and p73 exist in different isoforms that are well characterized. Isoforms have also been identified for p53 and it has been proposed that they are responsible for increased cancer metastasis.

View Article and Find Full Text PDF