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http://dx.doi.org/10.7704/kjhugr.2024.0042 | DOI Listing |
Background: Emergency department (ED) overcrowding has become a widespread global problem, with multi-factorial causes spanning input, throughput, and output domains. In Taiwan, the unique context of universal health coverage and a severe nursing shortage further complicates the situation. The Lunar New Year holiday period is associated with increased ED demand, yet the extent, causes, and responses to post-holiday overcrowding remain unclear.
View Article and Find Full Text PDFCell Signal
September 2025
Department of Anesthesiology and Operation, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, China. Electronic address:
Repeated exposure to gestational general anesthesia during pregnancy has been associated with neurodevelopmental damage and cognitive and social dysfunction in offspring. This study investigates the underlying mechanisms and therapeutic strategies for mitigating these effects. Behavioral tests revealed significant impairments in cognitive, social, and spatial learning abilities in the offspring of general anesthesia-treated mice, alongside delayed eye-opening, reduced body weight, and neuronal damage.
View Article and Find Full Text PDFAging Cell
September 2025
CREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD, Montpellier, France.
Aging, and by extension age-related diseases, has traditionally been understood through classical evolutionary genetic models, such as the mutation accumulation and antagonistic pleiotropy theories. However, these frameworks primarily focus on the declining efficacy of organismal-level selection against mutations with deleterious effects in late life. Here, we propose a novel hypothesis: many chronic diseases associated with aging may emerge, at least in part, as a result of selection acting at lower organizational levels, including non-replicative biological entities, enabled by the relaxation of selective pressures that constrained within-organism evolutionary processes in early life.
View Article and Find Full Text PDFFront Surg
August 2025
Department on Anesthesia and Surgery, Faculty of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Patulous Eustachian Tube (PET) dysfunction is a rare condition characterized by an abnormally open Eustachian tube, leading to symptoms such as autophony, auditory fullness, and pulsatile tinnitus. This case report describes a 48-year-old female weighing 72.4 kilograms who developed persistent autophony and hearing her own breathing and heartbeat sounds following significant weight loss after sleeve gastrectomy.
View Article and Find Full Text PDFStrabismus
September 2025
Department of Ophthalmology, Barcelona Hospital, Barcelona University, Barcelona, Spain.
: We report a case of an unusual association between Duane retraction syndrome and Marcus Gunn jaw-winking syndrome in the eye of a patient without other anomalies.: Clinical case. A four-year-old boy presented mild blepharoptosis of the left upper eyelid.
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