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Article Abstract
Background: Quercetin is a naturally occurring flavonoid abundant in various fruits and vegetables, known for its broad pharmacological properties, including antioxidant, anti-inflammatory, anti-apoptotic, and anti-fibrotic effects. Emerging evidence suggests that quercetin exerts protective roles in a range of ovarian-related reproductive disorders.
Purpose: This review aims to comprehensively summarize and critically assess current evidence on the therapeutic potential and molecular mechanisms of quercetin in the treatment of ovarian-related reproductive conditions. The goal is to provide a scientific foundation for its prospective clinical applications in female reproductive health.
Methods: A systematic search was conducted in major scientific databases, including PubMed, Web of Science, and ScienceDirect, covering literature published up to February 2025. The search strategy utilized a combination of keywords-"Quercetin", "Ovarian", "Polycystic Ovary Syndrome", "Premature Ovarian Failure", "Ovarian Dysfunction", "Premature Ovarian Insufficiency", and "Infertility"-combined using Boolean operators (AND, OR).
Results: Quercetin has demonstrated therapeutic efficacy in multiple ovarian conditions, including ovarian aging, polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), and chemotherapy-induced ovarian damage. Mechanistic studies reveal that quercetin modulates several critical biological pathways, particularly those involved in oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, and steroid hormone biosynthesis.
Conclusion: This review underscores the potential of quercetin as a promising therapeutic agent for managing ovarian-related reproductive disorders. Given its diverse biological activities, quercetin may offer significant clinical benefits in female reproductive medicine. Nonetheless, further investigations are warranted to determine its long-term efficacy, optimal dosing strategies, and specific molecular targets across various ovarian pathologies.
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| http://dx.doi.org/10.1016/j.phymed.2025.156945 | DOI Listing |
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