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Two abietane diterpenoids, named teuvismine A () and B (), along with two new taraxerane-type triterpenes, named teuvisoic acid A () and B () were isolated from whole plants of . The structures were elucidated by the analysis of HRESIMS spectroscopy and NMR spectroscopy, as well as the comparison with published data. All isolates were evaluated for their cytotoxic activities against five human cancer cell lines (HCT116, H460, HepG2, BGC823, and HeLa cells). Compound 3 showed moderate cytotoxic activities against HCT116 and H460 with IC values of 6.2 and 8.6 μM, respectively.
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http://dx.doi.org/10.1080/14786419.2025.2514733 | DOI Listing |
Biol Pharm Bull
August 2025
Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Cell transplantation therapy is a promising new treatment for myocardial infarction and heart failure. Developing methods to promote the engraftment of cardiac stem cells into cardiac tissue and their differentiation into cardiac cells is a strategy for improving the efficacy of cell transplantation therapy. Tanshinone VI (TanVI), a component extracted from the roots of Salvia miltiorrhiza Bunge (Labiatae), is a possible pharmacological agent for ischemic heart disease.
View Article and Find Full Text PDFBioorg Chem
August 2025
Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650504, PR China. Electronic address:
Taxascendins A - D (1-4), four unprecedented hetero-oligomeric terpenoids, and taxascendins E - K (5-11), seven new diterpenoids with five distinct and highly modified abietane-types frameworks, along with sixteen known analogues (10-27) were obtained from Taxodium ascendens. Their structures were determined by extensive spectroscopy, single-crystal X-ray diffraction, and quantum chemical calculations. Bioactivity screening indicated that the isolated compounds exhibited inhibitory activity in colorectal cancer cells.
View Article and Find Full Text PDFTheranostics
August 2025
School of Pharmaceutical Sciences, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
The limitations of current depression treatments highlight the importance of developing new therapeutic strategies. Tanshinone I (Tan I), a naturally occurring lipophilic diterpene compound, has promising activities including inflammation inhibition, cellular autophagy or apoptosis modulation, and anti-oxidative stress. However, the potential antidepressant effects of Tan I and the mechanism behind its action have yet to be established.
View Article and Find Full Text PDFAm J Chin Med
August 2025
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, P. R. China.
Oxidative stress serves as a driving force for myofibroblast activation in pulmonary fibrosis (PF). As a main enzymatic source of reactive oxygen species (ROS), NADPH oxidase 4 (Nox4) plays a critical role in modulating myofibroblast activation, and has thus emerged as a potential therapeutic target for PF. Tanshinone IIA (Tan-IIA), the most abundant fat-soluble component found in the root and rhizome of Bge.
View Article and Find Full Text PDFOrg Lett
August 2025
Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Herein, we present two 17(15→16)--abietane diterpenoids ( and ) as the first terpenoid-class Na1.8 inhibitors, along with their first asymmetric total syntheses to enable in-depth pharmacological studies. Key steps include kinetic resolution of terminal epoxides, bioinspired polyene cyclization, and late-stage photocatalytic benzylic oxidation.
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