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Background: The prevalence of vulvar diseases has a significant impact on quality of life (QoL). Measurement may not be consistently collected during assessments. Incorporating a QoL measurement tool may help optimize patient-centred care.
Objective: To determine the impact of the validated Vulvar Quality of Life Index (VQLI) questionnaire during consultation assessments.
Methods: A randomized controlled trial from a single dermatology centre was completed over 10 months. The intervention group completed the VQLI at the baseline/initial appointment, and both the intervention and control groups completed the questionnaire at follow-up, with these scores compared. Secondary outcomes compared scores within the intervention group; analyzed treatment adherence; and surveyed self-reported symptom improvement, whether patient health-related concerns were addressed, and well-being. Data were analyzed descriptively, with significance between means and proportions assessed using -tests and Fisher's exact tests, respectively.
Results: Forty-two patients participated. Scores within the intervention group, baseline (18) versus follow-up (8.3), were statistically significant. Follow-up VQLI scores in the intervention group (n = 23), 8.3, trended lower than the control (n = 19), 12.8, but were not statistically significant ( = .1529). Although treatment adherence ( = .428), symptom improvement ( = .684), and feeling of whether health-related concerns were addressed ( = .391) were similar, improvement in well-being ( = .017) in the intervention group was statistically significant.
Conclusions: In addition to the use of VQLI in vulvar dermatology assessments as an aid in identifying the impact of vulvar conditions on QoL, we recommend its use to improve the patients' sense of well-being.
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http://dx.doi.org/10.1177/12034754251347552 | DOI Listing |
Am J Biol Anthropol
September 2025
Magyar Gyula Horticultural, Technical and Vocational Training School, Budapest, Hungary.
Objectives: This study explores cranial morphological variation and population continuity in the Carpathian Basin from the 1st to 13th centuries CE. It focuses on assessing biological differences and similarities across major archaeological periods, with particular emphasis on the Avar, Hungarian Conquest, and Árpádian Age populations.
Materials And Methods: A total of 1,597 adult crania (864 males, 733 females) were analyzed using six neurocranial measurements.
Head Neck
September 2025
Department of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Background: Salvage surgery (SS) is one of the best treatment options for recurrent oropharyngeal squamous cell carcinoma (OPSCC) after prior definitive radiation.
Methods: A Medline literature search of articles on open (OSS) and transoral robotic surgery (TORS) for the treatment of recurrent OPSCC was performed. Surgical, functional, and oncological outcomes were analyzed and compared.
Hum Brain Mapp
September 2025
Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, Georgia, USA.
Investigating neuroimaging data to identify brain-based markers of mental illnesses has gained significant attention. Nevertheless, these endeavors encounter challenges arising from a reliance on symptoms and self-report assessments in making an initial diagnosis. The absence of biological data to delineate nosological categories hinders the provision of additional neurobiological insights into these disorders.
View Article and Find Full Text PDFPediatr Transplant
November 2025
Division of Urology, University of Toronto, Toronto, Canada.
Introduction: Differentiating acute tubular necrosis (ATN) from rejection in pediatric kidney transplant (KT) recipients remains challenging and necessitates invasive biopsy. Doppler ultrasound-derived resistive index (RI) is a noninvasive modality to assess graft status, but its diagnostic utility in children is unclear. This study evaluates RI's ability to distinguish ATN and rejection in KT.
View Article and Find Full Text PDFStroke
September 2025
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia. (V.Y., B.C.V.C., L.C., L.O., M.W.P.).
Background: To assess the efficacy and safety of tenecteplase in patients presenting within 24 hours of symptom onset with a large vessel occlusion and target mismatch on perfusion computed tomography.
Methods: ETERNAL-LVO was a prospective, randomized, open-label, blinded end point, phase 3, superiority trial where adult participants with a large vessel occlusion, presenting within 24 hours of onset with salvageable tissue on computed tomography perfusion, were randomized to tenecteplase 0.25 mg/kg or standard care across 11 primary and comprehensive stroke centers in Australia.