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Flow diverter (FD) is often the first-line treatment for giant internal carotid artery aneurysms, with a high rate of aneurysm occlusion. However, up to 10% of giant cerebral aneurysms increase in size after FD treatment. Surgery is usually considered if the giant internal carotid artery aneurysm continues to enlarge and cause compression. We report a case of a giant internal carotid artery aneurysm that continued to increase in size after FD treatment and was subsequently treated surgically. We also review the literature on the management of giant cerebral aneurysms that increased in size after FD. A 41-year-old female patient was diagnosed with a right giant internal carotid artery aneurysm and was initially treated with FD. After FD, the patient's vision in the right eye did not improve. Despite medical treatment, her vision continued to deteriorate. The patient presented at our hospital with reduced vision in both eyes. Magnetic resonance imaging and digital subtraction angiography with balloon test occlusion confirmed the presence of a giant thrombosed aneurysm in the right internal carotid artery, compressing the right optic nerve and optic chiasm. The patient underwent external carotid artery-middle cerebral artery bypass surgery using a radial artery graft, aneurysm sac dissection with thrombus removal, and reconstructive clipping of the aneurysm neck. After surgery, the patient's vision in both eyes improved immediately and did not develop any new neurological symptoms. Extracranial-intracranial arterial reconstructive surgery is a viable option for treating giant internal carotid artery aneurysms that have undergone FD treatment but continue to present with progressive mass effects.
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http://dx.doi.org/10.1055/s-0045-1805019 | DOI Listing |
Clin Neuroradiol
September 2025
Department of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Background: Pediatric acute ischemic stroke is a rare yet severe condition with multifactorial etiology, often associated with vasculopathies. Endovascular intervention in children with focal cerebral arteriopathy is seldom reported.
Purpose: Our aim was to report feasibility of intracranial rescue stenting for the management of pediatric focal cerebral arteriopathy with flow-limiting stenosis.
J Korean Med Sci
September 2025
Department of Neurosurgery, Korea University Anam Hospital, College of Medicine, Korea University, Seoul, Korea.
Background: Alzheimer's disease (AD) and vascular dementia (VaD) have distinct pathognomonic features, but they frequently co-occur as mixed dementia (MD) in elderly adults. This study aimed to develop a novel MD mouse model using bilateral carotid artery stenosis (BCAS) in 5 times familial Alzheimer's disease (5xFAD) transgenic mice and characterize its behavioral and histological features.
Methods: Thirteen C57BL/6 and sixteen 5xFAD transgenic mice were prepared.
Medicine (Baltimore)
September 2025
Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Chronic cerebral artery occlusion is an important cause of cerebral ischemic events. Endovascular recanalization is an effective treatment for this condition, but its success depends on appropriate patient selection and assessment. This is a retrospective study that collected patients with chronic cerebral artery occlusion who underwent endovascular recanalization to determine how imaging features from computed tomography angiography - including the extent of internal carotid artery occlusion, the number of calcified vessels, and the degree of calcification in the occluded vessels - affect the success rate of recanalization.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Al Mouwasat University Hospital, Damascus University, Damascus, Syria.
Rationale: Systemic sclerosis (SS) is an immune-mediated connective disease characterized by skin fibrosis, microvascular damage, and multisystem manifestations. One of the most important processes in connective tissue disorders is vasculitis. The clinical findings can differ when the disease is presented with an antineutrophil cytoplasmic antibody.
View Article and Find Full Text PDFJ Neurointerv Surg
September 2025
Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin Medical University, Tianjin, China
Background: Despite successful mechanical thrombectomy (MT), approximately 50% of patients with large vessel occlusion (LVO) stroke experience poor outcomes due to reperfusion injury. Intra-arterial infusion of human serum albumin (HSA) may offer neuroprotective benefits; however, its safety and feasibility have not been established when delivered via the internal carotid artery. In this study we aimed to evaluate the safety and technical feasibility of HSA infusion through the guiding catheter placed during MT in patients with anterior circulation LVO stroke following successful reperfusion.
View Article and Find Full Text PDF