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This study presents an economical experimental platform designed to investigate colloid and emulsion mixing under parabolic flight conditions. The compact 20 kg system integrates a modular fluidic device with real-time imaging capabilities to enable the observation of fluid interactions at the millimeter scale. The platform focuses on safety, like a double containment system, while remaining accessible for quick experimental modifications. Experiments using four distinct colloids, Thailand Lunar Simulant (TLS-01A), emulsions with Span 80 (50% v/v) and Tween 80 (10% v/v), and a control without additives, enabled analysis of surface tension and particle effects on mixing behavior. Through 29 experimental trials during parabolic flight cycles, each with approximately 20 s of microgravity, the system captured fluid dynamics at 240 frames per second. The platform enables future research to observe effects of surfactant and mixer geometry in real-world scale, with potential for improvements in automation and imaging capabilities. Using a simple measure of color distribution entropy, the Span 80 sample exhibited the highest degree of mixing, with a 24.2% improvement over the microgravity control and a 19.4% increase relative to ground-based Span sample.
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http://dx.doi.org/10.1038/s41598-025-04368-8 | DOI Listing |
Physiol Rep
September 2025
Human Adaptation Institute, Marseille, France.
Long-duration space missions will challenge astronauts' adaptive capacities. Interoception and heart rate variability (HRV), reflecting parasympathetic activity, are increasingly recognized as predictors of adaptation and health. This study investigated whether artificial intelligence may predict adaptation profiles from interoceptive and HRV responses accross different space analogs.
View Article and Find Full Text PDFBiosensors (Basel)
July 2025
Harvard-MIT Division of Health Sciences and Technology (HST), Boston, MA 02139, USA.
Measurable changes in electrophysiology have been documented in spaceflight, creating a pathway for disease genesis and progression in astronauts. These electrophysiology changes can be measured using potential difference (PD). A probe to measure PD was developed and is used clinically on Earth; this probe relies on fluid perfusion to establish an electrical connection to make PD measurements.
View Article and Find Full Text PDFLife Sci Space Res (Amst)
August 2025
Paracelsus Medical University, Salzburg, Austria; Rehabilitation Center Moorheilbad Harbach, Moorbad Harbach, Austria; Rehabilitation Center Lebens.Resort Ottenschlag, Ottenschlag, Austria.
This study aimed to examine the effects of weightlessness and microgravity, induced by parabolic flight, on specific biomarkers associated with angiogenesis, lipid homeostasis, and cardiovascular diseases, including angiogenin (ANG), angiopoietin-1 (ANGPT-1), angiopoietin-like protein 4 (ANGPTL4), heat shock protein 70 (HSP70), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and platelet-derived growth factor subunit AA (PDGF-AA). 14 healthy volunteers (mean age: 28.9 years; 6 females) participated in short-term sessions of weightlessness and microgravity using parabolic flights.
View Article and Find Full Text PDFLife Sci Space Res (Amst)
August 2025
Center for Space Medicine, Baylor College of Medicine, Houston, Texas, United States; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, United States; The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, United States; De
Parabolic flight serves as an important terrestrial analog to study acute physiological changes in microgravity without the need for space travel. During a parabolic flight, alternating hypergravity and microgravity phases, lasting up to 40 seconds, enable research into ophthalmic changes. In this review, we discuss the application of parabolic flight as a platform to study microgravity-related changes that might impact ophthalmology including intraocular pressure, intracranial pressure, choroidal blood flow, and modified eye movement patterns.
View Article and Find Full Text PDFExp Physiol
August 2025
Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon-Tyne, UK.
This case report evaluates whether it is possible to perform blood flow restriction (BFR) exercise during exposure to microgravity. The objectives were three-fold: (1) to determine if a personalised tourniquet system (PTS) hardware technology performs nominally and enables BFR exercise in microgravity; (2) to determine if BFR augments the exercise stimulus in microgravity in a similar manner to its application on Earth; and (3) to evaluate tolerance and acceptability of performing BFR exercise and operating the PTS hardware in microgravity. Two participants performed resistance squat and deadlift exercises on a flywheel device (inertia of 0.
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