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Background: In recent years, there has been a significant increase in the use of mechanical circulatory support devices, including the Impella device (Abiomed, Danvers, MA, USA), as hemodynamic support during high-risk percutaneous coronary intervention (PCI) and in acute management of cardiogenic shock.
Results: In this case series, we present two patients with non-ST-elevation myocardial infarction complicated by cardiogenic shock treated with Impella CP-protected PCI. After the revascularization, for both patients, a clinically relevant, access-site bleeding occurred, challenging the Impella CP maintenance. However, hemostasis was successfully achieved with a mechanical external compression device, allowing Impella hemodynamic support to continue.
Major Findings: In this case series we propose a novel and easy approach to manage access-site bleeding while using the Impella catheter.
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http://dx.doi.org/10.2459/JCM.0000000000001727 | DOI Listing |
ACS Macro Lett
September 2025
Pritzker School of Molecular Engineering, The University of Chicago, Chicago, Illinois 60637, United States.
Introducing dynamic covalent chemistries into polymer networks allows access to complex linear viscoelasticity, owing to the reversible nature of the dynamic bonds. While this macroscopic mechanical behavior is influenced by the dynamic exchange of these chemistries, connecting the microscopic dynamics to the bulk properties is hindered by the time scale conventional techniques can observe. Here, light scattering passive microrheology is applied to probe short-time dynamics of dynamic covalent networks that consist of telechelic benzalcyanoacetate (BCA) Michael acceptors and thiol-functionalized cross-linkers.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
September 2025
CRT 4, US Army Institute of Surgical Research Burn Center, Fort Sam Houston, Texas, USA.
Acute extremity compartment syndrome (CS) is a serious medical complication triggered by factors such as trauma, vascular injury, or prolonged compression, resulting in elevated intracompartmental pressure (ICP) and tissue ischemia. Diagnosis remains challenging, mainly relying on the subjective evaluation of clinical symptoms. Different animal models have been used to study pathophysiology and evaluate diagnostic and therapeutic approaches.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China.
Gel-based electronic skin (e-skin) has recently emerged as one of the most promising interfaces for human-machine interaction and wearable devices, owing to its exceptional flexibility, extensibility, transparency, biocompatibility, high-quality physiological signal monitoring, and system integration suitability. However, conventional hydrogel-based e-skins may exhibit limitations in mechanical strength and stretchability compatibility, as well as poor environmental stability. To address these challenges, following a top-down fabrication strategy, this study innovatively integrates poly(methacrylic acid), titanium sulfate, and ethylene glycol (EG) into the three-dimensional collagen fiber network structure of zeolite-tanned sheepskin to successfully develop an organogel (SMEMT) e-skin, which exhibits superior high toughness, environmental stability, high transparency (74% light transmittance at 550 nm), antibacterial properties and ecological compatibility.
View Article and Find Full Text PDFPlant Biol (Stuttg)
September 2025
Department of Botany and Center for Biotechnology, Plant Physiology Laboratory, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Erythrina velutina is a tree that thrives in the shallow rocky soils of the dry and hot Caatinga, a unique Brazilian biome. It is rich in specialized metabolites with medicinal properties. Indeed, alkaloids and flavonoids are phytochemical markers of the genus.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Mathematical and Statistical Methods (Biometris), Wageningen University, Wageningen, The Netherlands.
Many plant cell functions, including cell morphogenesis and anisotropic growth, rely on the self-organisation of cortical microtubules into aligned arrays with the correct orientation. An important ongoing debate is how cell geometry, wall mechanical stresses, and other internal and external cues are integrated to determine the orientation of the cortical array. Here, we demonstrate that microtubule-based nucleation can markedly shift the balance between these often competing directional cues.
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