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Objectives: This study aimed to explore the relationship between chronotype and two key occupational health outcomes-work ability and health-related productivity loss-in the general working population of Korea. The research further sought to identify subgroup variations by demographic and occupational factors.
Methods: Data were derived from the Korean Work, Sleep, and Health Study (KWSHS), a nationwide panel study conducted between 2022 and 2024. Chronotype was assessed using the reduced Morningness-Eveningness Questionnaire (rMEQ), categorizing participants as morning, intermediate, or evening types. Work ability and health-related productivity loss were measured using the Work Ability Index (WAI) and the Work Productivity and Activity Impairment Questionnaire (WPAI), respectively. Generalized estimating equation models were employed to estimate odds ratios for poor work ability and mean differences in health-related productivity loss, adjusting for demographic and occupational factors.
Results: Evening chronotypes exhibited significantly higher odds of poor work ability (adjusted odds ratio: 2.291, 95% CI: 1.717-3.058) and greater health-related productivity loss (mean difference: 5.362%, 95% CI: 3.902-6.822) compared to morning types. Intermediate types demonstrated moderately elevated risks. Subgroup analyses revealed that evening-type men, younger workers, and white-collar employees experienced the greatest disparities. Conversely, the impact of chronotype on shift workers was less pronounced.
Conclusions: Chronotype significantly influences work ability and health-related productivity loss, with evening types experiencing the poorest outcomes due to circadian misalignment. These findings suggest the importance of considering chronotype in workplace health interventions. Strategies such as flexible schedules and sleep health programs may mitigate productivity losses and enhance employees' well-being.
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http://dx.doi.org/10.1016/j.sleh.2025.04.005 | DOI Listing |
J Eval Clin Pract
September 2025
Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan.
Rationale: Physicians sometimes encounter various types of gut feelings (GFs) during clinical diagnosis. The type of GF addressed in this paper refers to the intuitive sense that the generated hypothesis might be incorrect. An appropriate diagnosis cannot be obtained unless these GFs are articulated and inventive solutions are devised.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
Major in Bionano Engineering, School of Bio-Pharmaceutical Convergence, Hanyang University, Ansan, 155-88, Republic of Korea.
Membrane proteins are essential bio-macromolecules involved in numerous critical biological processes and serve as therapeutic targets for a wide range of modern pharmaceuticals. Small amphipathic molecules, called detergents or surfactants, are widely used for the isolation and structural characterization of these proteins. A key requirement for such studies is their ability to maintain membrane protein stability in aqueous solution, a task where conventional detergents often fall short.
View Article and Find Full Text PDFTransfusion
September 2025
Department of Human Genetics, The University of Utah School of Medicine, Salt Lake City, Utah, USA.
Background: Although blood group variation was first described over a century ago, our understanding of the genetic variation affecting antigenic expression on the red blood cell surface in many populations is lacking. This deficit limits the ability to accurately type patients, especially as serological testing is not available for all described blood groups, and targeted genotyping panels may lack rare or population-specific variants.
Study Design And Methods: Here, we perform serological assays across 24 antigens and whole genome sequencing on 100 Omanis, a population underrepresented in genomic databases.
J Hum Nutr Diet
October 2025
School of Health, Medicine and Life Sciences, University of Hertfordshire, Hatfield, UK.
Background: Evidence suggests that women should eat a healthy diet during pre-conception and pregnancy as this benefits their own health as well as reducing the risk of non-communicable diseases in offspring (such as obesity, diabetes, hypertension, cardiovascular and mental health problems); however, previous work indicates that the recommendations are not being followed. This study aimed to understand: the facilitators and barriers to healthy food and diet practices during pre-conception and pregnancy; how these barriers could be addressed, and the changes required to facilitate good food practices.
Methods: The research used a qualitative approach; five online focus groups were undertaken with 19 women living across the UK who were trying to conceive, pregnant or had babies under 6-months old.
Bioorg Chem
August 2025
Key Lab of Protein Structure and Function of Universities in Hunan Province, University of South China, Hengyang, Hunan 421001, China; School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China. Electronic address:
Inhibition of human monoamine oxidase B (hMAO-B) to prevent both oxidative stress and lipid metabolism disorders, which are high-risk factors for pathogenesis of atherosclerosis, is a potential strategy for the treatment of atherosclerosis. In this study, we have explored a series of C-3 nitrothiophene substituted thiochromone analogues that showed good to excellent potency against hMAO-B. The strategy of introduction the nitro-group into thiophene linker, which contributes pivotal interactions with Cys172, significantly improved the potency and selectivity of these compounds.
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