Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Sleep disorders may impair the nervous and immune systems. In thyroid eye disease (TED), an autoimmune condition, sleep quality and its potential determinants remain unclear. The study aimed to assess the sleep quality of patients with TED and identify its determinants.
Method: A questionnaire was used to collect the clinical information of patients with TED and controls in a hospital. The data included the participants' demographic characteristics, the Pittsburgh Sleep Quality Index (PSQI) score, and Self-rating Anxiety Scale (SAS) score. The sleep quality was compared between the TED and control groups. Furthermore, binary logistic regression analysis was used to detect the determinants of sleep quality, while linear regression was used to evaluate the relationships between PSQI and potential determinants.
Results: Overall, 52 patients with TED and 75 healthy individuals were enrolled in this study. In the TED group, 59.6% of patients experienced sleep disorders, compared to only 33.3% in the control group. Additionally, the PSQI scores of patients with TED tended to be higher than those of controls (p = 0.002). Binary logistic regression revealed that a high SAS score was an independent risk factor for poorer sleep quality in patients with TED. Furthermore, patients with TED with higher GO-QoL visual function scores tended to have lower sleep scores.
Conclusions: Patients with TED often experience sleep disorders, which are related to anxiety and visual impairment. Sleep disorders should be considered in managing patients with TED in clinical practice.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131440 | PMC |
| http://dx.doi.org/10.1186/s40001-025-02691-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
MediTEDNet: Visual State Space Model for Thyroid Eye Disease Classification.
IEEE J Biomed Health Inform
September 2025
Thyroid eye disease (TED) is a prevalent autoimmune orbital disorder that can severely impair visual function and significantly diminish patients' quality of life. In recent years, several studies have attempted to automate TED diagnosis using optical coherence tomography (OCT) images. However, existing approaches primarily rely on convolutional neural networks (CNNs) combined with attention mechanisms and are mostly trained using traditional cross-entropy loss.
View Article and Find Full Text PDFSparking malignancy: nicotine as a driver of stemness and metastasis in triple-negative breast cancer.
J Pathol
September 2025
Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.
Triple-negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor (PR), and HER2, and remains one of the most aggressive and therapeutically challenging breast cancer subtypes, marked by early relapse, metastasis, and limited targeted treatment options. In a recent study published in The Journal of Pathology, Kuo et al provide compelling evidence that nicotine exposure, whether from tobacco smoke or e-cigarette vapor, drives TNBC progression by promoting stem-like and metastatic phenotypes. Integrating clinical datasets, patient tissues, cell lines, and in vivo models, the authors demonstrate that nicotine enhances tumor aggressiveness via coordinated upregulation of CHRNA9 and IGF1R.
View Article and Find Full Text PDF[Outcomes of modified lateral orbital wall decompression using ultrasonic bone removal].
Vestn Oftalmol
September 2025
National Medical Research Center for Endocrinology, Moscow, Russia.
Objective: This study presents a comparative analysis of outcomes of lateral orbital wall decompression performed using ultrasonic bone removal with standard and modified techniques.
Material And Methods: The study included 78 patients (109 orbits) with exophthalmos without visual impairment (subgroups 1A and 1B) and with optic neuropathy (ON) due to thyroid eye disease (TED) (subgroups 2A and 2B). Lateral wall decompression (LWD) was performed using ultrasonic bone removal with a modified (=58, patient subgroups 1A and 2A) or standard (=51, subgroups 1B and 2B) technique.
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.
Nature
September 2025
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Cardiolipin (CL) is the signature phospholipid of the inner mitochondrial membrane, where it stabilizes electron transport chain protein complexes. The final step in CL biosynthesis relates to its remodelling: the exchange of nascent acyl chains with longer, unsaturated chains. However, the enzyme responsible for cleaving nascent CL (nCL) has remained elusive.
View Article and Find Full Text PDF[Clinical efficacy of in-situ crown reattachment technique combined with pulpotomy in the treatment of complica-ted crown-root fractures of young permanent anterior teeth].
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2025
Key Laboratory of Shaanxi Province for Craniofacial Precison Medicine Research, Hospital of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
Objectives: This study aimed to evaluate the clinical application value of in-situ crown reattachment technique combined with pulpotomy in the treatment of complicated crown-root fractures in young permanent anterior teeth.
Methods: A prospective study was conducted on 50 children with complicated crown-root fractures in young permanent anterior teeth, who were treated at the Pediatric Dentistry Department, Hospital of Stomatology, Xi'an Jiaotong University from June 2023 to June 2024. All patients underwent in-situ crown reattachment technique combined with pulpotomy.