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http://dx.doi.org/10.4103/aian.aian_147_25 | DOI Listing |
Inflamm Res
September 2025
Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.
Interleukin-17 (IL-17) has emerged as a key cytokine at the intersection of inflammation and thrombosis, potentially playing a pivotal role in thromboinflammation. This review explores the mechanistic contributions of IL-17 to endothelial dysfunction, platelet activation, monocytes activation, and neutrophil extracellular trap (NET) formation, which collectively promotes a pro-thrombotic state. We summarize findings from experimental models and clinical studies linking IL-17 to thrombosis in autoimmune diseases, atherosclerosis, and infectious diseases such sepsis and COVID-19.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail -1902, Bangladesh. Electronic address:
Rheumatoid arthritis (RA) raises the incidence of Diffuse large B-cell lymphoma (DLBCL) development, presenting a critical clinical challenge due to the intersection of autoimmunity and malignancy. However, molecular mechanisms underlying RA-mediated DLBCL progression and therapeutic interventions remain poorly elucidated. To address this gap, we developed a novel GCNConv deep learning pipeline to predict key molecular hubs within shared genes of RA and DLBCL networks and validated them through literature mining.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Translational Biomedicine and Neuroscience (DiBraiN), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", I-70124 Bari, Italy.
The fibrotic progression of diseases is characterized by the excessive deposition of extracellular matrix (ECM) proteins, leading to an alteration in tissue structure, often based on the activation of epithelial-to-mesenchymal transition (EMT). This can lead to decreased or completely impaired organ function, compromising quality of life and affecting vital organs. Fibrotic phenomena have recently been observed in autoimmune diseases and are correlated with the activation of transduction cascades that trigger chronic inflammation.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Guangzhou University of Chinese Medicine, Guangzhou, China.
Rheumatoid arthritis (RA) is a prevalent autoimmune disorder that significantly reduces quality of life and imposes a substantial burden on society. This study addresses the critical gaps in current diagnostic and therapeutic modalities by aiming to identify improved biomarkers and potential therapeutic targets. Using data from 2 gene expression omnibus databases, we executed a comprehensive differential gene expression analysis integrated with Mendelian randomization.
View Article and Find Full Text PDFJ Orthop
November 2025
Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA, USA.
Introduction: Psoriasis is an autoimmune inflammatory condition that often intersects with orthopaedic care due to its connection to psoriatic arthritis. However, not all psoriasis patients develop psoriatic arthritis. Psoriasis patients may undergo hip or knee arthroplasties for reasons unrelated to psoriasis.
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