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Purpose: This preliminary study investigated the effectiveness of conventional ultrasound (US) and Doppler US in evaluating rectosigmoid ratio (R/S) and blood flow dynamics in children with functional constipation (FC).
Methods: A total of 62 children aged 5-18 years were enrolled, including 32 patients with FC and 30 healthy controls. Rectal and sigmoid diameters, R/S ratio, and mesenteric blood flow parameters (PSV, PI, and RI) were assessed using standardized US and Doppler US techniques before and after a three-month treatment regimen including behavioral therapy and osmotic laxatives.
Results: The R/S ratio significantly improved after treatment in the FC group (p = 0.036), while no significant changes were observed in mesenteric blood flow velocities or resistive indices. Patients with R/S ≥ 1 had significantly lower celiac artery PSV values compared to those with R/S < 1 (p = 0.009).
Conclusions: While Doppler US did not yield substantial clinical benefits in assessing intestinal blood flow in FC, the non-invasive evaluation of the R/S ratio proved useful in monitoring treatment response. This preliminary study suggests that rectosigmoid measurements may aid in patient management and calls for further research with larger cohorts.
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http://dx.doi.org/10.1007/s00261-025-05009-4 | DOI Listing |
Int J Gen Med
September 2025
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Background: Nodular hidradenoma (NH) is a rare benign adnexal tumor originating from sweat glands, often misdiagnosed due to nonspecific clinical manifestations. Ultrasonography (US) plays a critical role in the diagnosis of skin tumors, yet systematic descriptions of its sonographic features remain limited.
Objective: This study aims to investigate the very-high-frequency (VHF) characteristics of eccrine nodular hidradenoma (ENH) and establish key imaging criteria to differentiate it from other cutaneous/subcutaneous lesions.
Curr Dev Nutr
September 2025
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, United States.
Background: The objective of this study was to compare the effects of daily consumption of white potatoes compared with white rice on cardiometabolic health in individuals with type-2 diabetes (T2D).
Objective: To determine the effects of white potato consumption compared to white rice (a commonly consumed refined grain) on indices of glycemic control and cardiovascular health in individuals with overweight or obesity and T2D.
Methods: In this randomized crossover study, comparative control trial, 24 adults with T2D [45-80 y, body mass index (kg/m) 25-40] consumed baked white potatoes (100 g) or calorie-matched white rice (75 g) daily for 12 wk, separated by a 2-wk washout, with assessments of glycemic control, lipids, inflammation, blood pressure, endothelial function, and body composition at baseline (only 1 baseline visit included as a covariate in statistical analyses), 6 wk, and 12 wk.
Biochem Biophys Rep
December 2025
Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Introduction: 5-Hydroxymethyl furfural (5-HMF) is a furan compound with a molecular formula of CHO. Studies have found that 5-HMF has many pharmacological effects, such as improving hemorheology, anti-inflammatory, antioxidant activity and anti-myocardial ischemia. Identifying the preventive effect of 5-HMF against ischemic stroke and its possible mechanism was the aim of this investigation.
View Article and Find Full Text PDFExp Ther Med
November 2025
Department of Neurosurgery, Nanchong Shenxin Hospital, Nanchong, Sichuan 637003, P.R. China.
Wide-necked anterior communicating artery (ACoA) aneurysms pose challenges for endovascular coiling due to the risk of coil protrusion. This case report describes a new endovascular technique for managing ruptured wide-necked ACoA aneurysms, addressing the risk of coil protrusion during embolization. This method employs a combined microcatheter and guidewire-assisted embolization method, enabling coil deployment without needing adjunctive devices such as stents or balloons.
View Article and Find Full Text PDFFront Oncol
August 2025
Department Hematopathology, Shenzhen Hospital of Southern Medical University, Shenzhen, China.
Background: Mixed-phenotype acute leukemia (MPAL) is a rare acute leukemia for which data are currently not available to guide therapy. It has a poor outcome, particularly in elderly patients.
Case Presentation: We report the successful use of venetoclax/azacitidine as treatment for a treatment-naive elderly patient with early T-cell precursor (ETP)/myeloid MPAL.