98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/all.16609 | DOI Listing |
Clin Transplant
September 2025
Centro De Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico.
Clin Lab
September 2025
Background: Light chain multiple myeloma (LCMM) is a malignant hematological disease characterized by bone marrow infiltration by tumor plasma cells and the secretion of monoclonal free light chains (κ or λ). It is often di-agnosed through hypogammaglobulinemia detected by serum protein electrophoresis, followed by immunotyping showing a monoclonal band in free light chains. However, the structure of monoclonal light chains can sometimes complicate laboratory findings.
View Article and Find Full Text PDFAm J Reprod Immunol
September 2025
Department of Molecular Biology and Genetics, Tokat Gaziosmanpasa University, Tokat, Turkey.
Int J Surg Case Rep
September 2025
Clinical Immunology Research Center, Ali-Ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Internal Medicine and Virology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Cell Prolif
September 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, China.
ARPC1B cancer stem cells (CSCs) in pancreatic cancer are identified as a subpopulation resistant to gemcitabine. In our study, drug repositioning, molecular docking, and surface plasmon resonance (SPR) technique jointly revealed that CK-636 can directly target ARPC1B protein with high affinity. In vitro cytotoxicity, ex vivo organoid cultures, in vivo xenograft and orthotopic gemcitabine-resistant pancreatic cancer model demonstrated that combination therapy of gemcitabine plus CK-636 showed a superior anti-tumor effect compared with gemcitabine monotherapy.
View Article and Find Full Text PDF