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Introduction: Lifestyle factors such as physical and cognitively stimulating activities may protect against various diseases. However, only a few simple and validated questionnaires assess the lifestyle factors in Japan. Thus, we aimed to create Japanese versions of such questionnaires for assessing physical and cognitively stimulating activities. This study examined their inter-rater reliability and test-retest reproducibility.
Methods: We developed a Japanese version of questionnaires by translating the English questionnaire that assesses the frequency of several physical and cognitively stimulating activities. Additionally, the Japanese version assesses the duration of engagement in physical activities, and we have added mental activities such as meditation and Zen practice. The inter-rater reliability and test-retest reproducibility of evaluating the frequency, duration, frequency × duration of each physical activity, and frequency of each cognitively stimulating activity were tested in healthy volunteers.
Results: The study included 48 participants aged 25-67 years. We observed good inter-rater reliability and test-retest reproducibility for the physical and cognitively stimulating activity questionnaires. As a pilot approach, we calculated the Total Physical Activity Score (metabolic equivalents·min/week) with an intraclass correlation coefficient (ICC) (2,1) of 0.818 (95% confidence interval, 0.698-0.894), indicating good test-retest reproducibility.
Conclusions: The Japanese versions of questionnaires used to assess the frequency and duration of physical and cognitively stimulating activities generally have good inter-rater reliability and test-retest reproducibility. While introducing the duration of engagement might enable the estimation of the Total Physical Activity Score, further validation using objective measures of activities and other self-reported physical activity questionnaires is necessary, which is a limitation of this study.
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http://dx.doi.org/10.31662/jmaj.2024-0153 | DOI Listing |
Curr Biol
July 2025
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:
The claustrum (CLA) is a thin and elongated brain structure that is located between the insula and lateral striatum and is implicated in a wide range of behaviors. It is characterized by its extensive synaptic connectivity with multiple cortical regions. While CLA projection neurons are glutamatergic, several studies have shown an inhibitory impact of CLA on its cortical targets, suggesting the involvement of inhibitory cortical interneurons.
View Article and Find Full Text PDFFront Hum Neurosci
September 2025
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Primary progressive aphasia (PPA) is a neurological syndrome characterized by the gradual deterioration of language capabilities. Due to its neurodegenerative nature, PPA is marked by a continuous decline, necessitating ongoing and adaptive therapeutic interventions. Recent studies have demonstrated that behavioral therapies, particularly when combined with neuromodulation techniques such as transcranial direct current stimulation (tDCS), can improve treatment outcomes, including the long-term maintenance and generalization of therapeutic effects.
View Article and Find Full Text PDFFront Surg
August 2025
Department of Neurology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czechia.
Introduction: Peri-lead edema (PLE) is a commonly observed but often asymptomatic complication of deep brain stimulation (DBS). While usually transient and benign, severe cases of PLE can result in neurological symptoms, impacting patient outcomes. This case series explores the clinical course, management, and outcomes of symptomatic PLE in a series of five patients undergoing DBS.
View Article and Find Full Text PDFAging is associated with cognitive decline, impaired spatial learning, and diminished brain function, significantly impacting quality of life (QoL). Emerging evidence suggests that lifestyle interventions, like omega-3 fatty acids (FAs) intake and regular exercise, can mitigate these age-related deficits by targeting key molecular pathways implicated in oxidative damage, inflammation, and reduced fibrinolytic activity. By doing so, omega-3 FAs, principally eicosapentaenoic acid and docosahexaenoic acid, influence signaling pathways that enhance synaptic plasticity, prevent apoptosis, and promote neurogenesis.
View Article and Find Full Text PDFIndian J Psychiatry
August 2025
Department of Psychiatry, Serenity Clinic, New Delhi, India.
Background: Cognitive deficits significantly contribute to the disability related to schizophrenia.
Aim: We aim to evaluate the efficacy of high-frequency rTMS intervention in the improvement of cognitive symptoms in schizophrenia.
Methods: One-hundred patients of predominantly negative schizophrenia having cognitive deficits were enrolled for this randomized, sham controlled, double-blind trial.