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Purpose: Many trials ask patients to complete patient-reported outcome measures (PROMs) via the web, excluding patients unable to use/access the Internet. The PRO-TECT trial (AFT-39, ClinicalTrials.gov identifier: NCT03249090) also offered a telephone interface option (interactive voice response [IVR]). We compared patients choosing IVR versus web on alert rates to nurses and clinical outcomes to determine if a telephone option can close disparities in symptom management.
Methods: PRO-TECT randomized 26 community oncology practices to the PROM intervention arm where concerning symptoms generated automated alerts to nurses. IVR and web patients were compared for social determinants of health (SDOH) using analysis of variance and chi-square tests. After accounting for clustering and confounders, we used generalized estimating equations to compare alert rates, mixed models for quality of life (QOL) at 3 months, and Cox regression for emergency visits and survival at 12 months.
Results: Among 593 patients, 215 (36%) chose IVR and 378 (64%) chose web. IVR patients were older (65.2 60.8 years) and were more often rural residents (32% 23%), Black (27% 11%), and with less education (54% 27% ≤high school; all < .01). Patients choosing IVR had more surveys with concerning symptoms (49% 37%) and nurses felt clinical attention was warranted more often (4.8 surveys 3.4 surveys; all < .001) but ultimately experienced similar benefits as web in QOL, emergency visits, and survival.
Conclusion: One third of community patients choose a telephone option over the web for reporting PROMs during cancer care. These patients are disproportionately from SDOH backgrounds at risk of poor clinical outcomes and have higher symptom management needs but ultimately experience similar clinical benefits as patients choosing the web. PROM programs should offer web alternatives to close disparities in symptom management.
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http://dx.doi.org/10.1200/CCI-25-00046 | DOI Listing |
Internet Interv
December 2025
eCentreClinic, School of Psychological Sciences, Macquarie University, NSW, Australia.
Psychological treatments for perinatal depression and anxiety are effective when delivered in-person or remotely. However, new and expectant mothers face considerable barriers to receiving mental health care, especially on an ongoing basis or when delivered in-person. Very brief digital treatments may be able to support women during this time using less time than existing treatments.
View Article and Find Full Text PDFF1000Res
September 2025
Norwegian Centre for Headache Research (NorHead), Norwegian University of Science and Technology, Trondheim, Norway.
Introduction: Biofeedback is a non-pharmacological treatment option valued for its minimal risk of adverse events and offers a safe alternative for individuals seeking preventive care for migraine. Despite level A evidence for migraine prevention, biofeedback treatment is still unavailable to most patients. We developed a novel medical device (Cerebri) for multimodal biofeedback treatment that omits the need for healthcare personnel involvement.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
University of Basel, Basel, Switzerland.
Background: Despite the increasing options for public and private health care providers in the Lao People's Democratic Republic (Lao PDR), choosing a high-quality provider or facility is difficult because timely and reliable information about providers is not readily available. Additionally, only 28% described their most recent visit to a health care provider as high quality, suggesting that while options for care are expanding, people may need support in finding providers that meet their quality needs. To inform efforts to improve access to high-quality care, evidence is needed on mechanisms that empower people to identify and use such care.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Importance: Remote blood pressure (BP) monitoring for hypertension has been limited by low participation and engagement.
Objective: To evaluate if an opt-out behavioral economic approach to remote BP monitoring improves enrollment and BP outcomes compared with an opt-in approach.
Design, Setting, And Participants: This pragmatic, 3-arm randomized clinical trial included patients aged 18 to 75 years with hypertension who were followed up by an academic family medicine practice in Philadelphia.
Clin Rheumatol
August 2025
Eli Lilly and Company, Indianapolis, IN, USA.
Objective: To assess the prevalence of undiagnosed axial spondyloarthritis (axSpA) in patients attending chiropractic clinics (CCs) with chronic back pain (CBP), using the Assessment of Spondyloarthritis International Society (ASAS) referral strategy.
Methods: An observational study of adults attending one of four CCs between November 2020-2021 with CBP starting before age of 45, without prior diagnosis of spondyloarthritis (SpA). Patients fulfilling ≥ 1 feature of SpA (Inflammatory back pain [IBP], a family history of SpA, inflammatory bowel disease, psoriasis, good response to NSAIDs, history of heel pain, uveitis, or peripheral arthritis) were referred to rheumatologists.