Anti-inflammatory and anti-proliferative activities of secondary metabolites isolated from the leaves of .

A new triterpenoid, 3,4-seco-29-hydroxyfriedelan-3-oic acid (), was obtained from the leafy parts of , along with eighteen previously identified compounds. These included four pentacyclic triterpenoids (-), two carotenoids ( and ), one flavanol dimer (), nine flavonoids (-), one megastigmane glycoside (), and one pentose (). A combination of spectroscopic techniques was employed for structural identification. Thirteen isolates (, , -, , and -) showed inhibitory activity in the macrophage NO production model, with IC values in the range (13.0 and 95.2 µM). Compound had the most potent effect (IC = 13.0 µM), which was comparable to that of dexamethasone. Compounds , and exerted pronounced anti-proliferative effects against Hep-G2, A549 and MCF-7 cell lines with IC values in the range (9.3 and 23.6 µM). This is the first phytochemical investigation of .