Two New Myrsinane-type Diterpenoids From the Aerial Parts of Jatropha integerrima Jacq. and Their Antimicrobial Activity.

In the search for new antimicrobial agents, this study investigated the phytochemical composition of the aerial parts of Jatropha integerrima, leading to the isolation of two new myrsinane-type diterpenoids, jatrophodiones F and G (1, 2), along with seven known compounds: jatrointelone A (3), α-tocospiro A (4), 8(14),15-sandaracopimaradien-3β-ol (5), curdione (6), 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (7), 7-oxo-β-sitosterol (8), and 3β-hydroxystigmast-5(6),22-diene-7-one (9). The structures of these compounds were elucidated via high-resolution electrospray ionization time-of-flight mass spectrometry and infrared, ultraviolet, and nuclear magnetic resonance spectroscopy, comparing the analyses with reported spectroscopic data. Compounds 1-3 and 5-9 exhibited moderate to strong activity against eight microorganisms, including Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, Staphylococcus aureus, Candida albicans, and Aspergillus brasiliensis, with minimum inhibitory concentrations (MICs) ranging from 32 to 256 µg/mL.

Anti-inflammatory and anti-proliferative activities of secondary metabolites isolated from the leaves of .

A new triterpenoid, 3,4-seco-29-hydroxyfriedelan-3-oic acid (), was obtained from the leafy parts of , along with eighteen previously identified compounds. These included four pentacyclic triterpenoids (-), two carotenoids ( and ), one flavanol dimer (), nine flavonoids (-), one megastigmane glycoside (), and one pentose (). A combination of spectroscopic techniques was employed for structural identification.

Eco-friendly extraction and recovery of triterpenoids from persimmon leaves ( L.f.) using ultrasound-assisted deep eutectic solvents and macroporous resins.

Triterpenoids are known for their promising biological activities, and there is a growing focus on green extraction methods for these compounds. In this study, ultrasound-assisted deep eutectic solvents were employed to extract triterpenoids from persimmon leaves, with choline chloride-lactic acid identified as an effective green solvent. The extraction conditions were carefully optimized using response surface methodology, resulting in an extraction efficiency of 12.

A new 14-membered cembrane-type diterpenoid and other constituents from the aerial parts of Jacq. and their antibacterial activity.

A new 14-membered cembrane- diterpenoid, jatrophainolide D (), along with six known compounds, ()-phytol (), lupeol (), stigmasterol (), ergosta-4,6,8 (14),22-tetraen-3-one (), stigmast-4-ene-3-one (), and ergosterol peroxide () were isolated from the aerial parts of . The structure of isolates was elucidated by IR, UV, 1D-/2D-NMR, and HRESI-TOFMS data as well as by comparison with the reported spectroscopic data. All isolates were evaluated the antibacterial activity against , , , , , and .

Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of .

Inflammation, a natural process of the innate immune system, involves elevated levels of various proinflammatory mediators, such as, nitric oxide (NO) and prostaglandin (PGE), cytokines such as interleukin 6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α), and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This study investigated the anti-inflammatory effects of homalolide A () and homalomenol A (), two sesquiterpenoids isolated from the rhizome of , on lipopolysaccharide (LPS)- stimulated macrophage cells. The results demonstrated that both and dose-dependently inhibited the production of PGE, TNF-α and IL-6 in RAW 264.

Adunctin E from Induces Apoptosis in Lung Cancer via HSP90AA1 Modulation: A Network Pharmacology and In Vitro Study.

Lung cancer stands out as a leading cause of death among various cancer types, highlighting the urgent need for effective anticancer drugs and the discovery of new compounds with potent therapeutic properties. Natural sources, such as the genus, offer various bioactive compounds. Adunctin E (AE), a dihydrochalcone derived from , exhibited several pharmacological activities, and its potential as an anticancer agent remains largely unexplored.

Essential Oil from Vietnamese Hook. & Arn. (Piperaceae): Chemical Composition, Antioxidant, Anti-Inflammatory, Cytotoxic Activities, and In Silico Analysis.

This study is the first to investigate the chemical composition and antioxidant, anti-inflammatory, and cytotoxic activities of leaf oil. A yellow oil was obtained through hydro-distillation, with a yield of 0.1% (/).

Conamonin A and dihydrochalcones from the whole plants of Conamomum rubidum (Lamxay & N.S.Lý) Škorničk. & A.D. Poulsen showing anti-inflammatory and cytotoxic activities.

A new compound, conamonin A (), was isolated from the whole plants of with eight known dihydrochalcones (-). Their structures were elucidated by a combination of spectroscopic methods as well as by comparison with previously reported data. The absolute configuration of was assigned by TDDFT-ECD method.

A green method to extract rutin from L.

L. contains high levels of rutin, which has great potential for use in pharmaceutical products for the treatment of diseases related to the cardiovascular and circulatory systems. We proposed a method of extracting rutin from by using a green solvent.

Chemical composition and biological activities of essential oil from leaves.

This study focused on the chemical composition and biological activities of the essential oil derived from , a plant species known for its medicinal properties. The analysis of essential oil revealed the presence of 78 constituents. The major compounds were -cadinol (13.

Conarubins A-D: Four Monoterpene-Chalcone Conjugates from and Their Anti-inflammatory and Cytotoxic Activities.

Four novel compounds, conarubins A-D (-), were isolated from the whole plants of collected in Vietnam. Their structures were elucidated by extensive spectroscopic analyses and by quantum chemical calculations of NMR and ECD. Compounds and were the first examples of monoterpene-monoterpene-chalcone conjugates in nature, whereas compound was an unprecedented monoterpene-substituted chalcone containing a 3,4,5-trioxygenated cyclohexa-2,5-diene-1-one ring.

Chemical composition and acetylcholinesterase inhibitory activity of essential oil from the leaves of Weeras. & R.M.K. Saunders.

The present study provides the first information on the chemical composition and acetylcholinesterase inhibitory activity of the essential oil (EO) from the leaves of Weeras. & R.M.

Isolation, structural elucidation, and cytotoxic activity investigation of novel styryl-lactone derivatives from : and studies.

Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of . Compound 1 is a newly discovered natural product, and compound 2 is reported in this plant for the first time. The absolute configuration of 1 was determined based on the ECD spectrum.

Aspidiatas C and D, two new spirostanol saponins from and their cytotoxic activities.

Aspidiatas C and D ( and ), two new spirostanol saponins, were isolated along with two known compounds, (25 )-spirost-5-en-3-yl -L-rhamnopyranosyl-(1→4)--L-rhamnopyranosyl-(1→4)-[-L-rhamnopyranosyl-(1→2)]--D-glucopyranoside (), (25 )-spirost-5-en-3-yl -L-rhamnopyranosyl-(1→4)--L-rhamnopyranosyl-(1→4)--D-glucopyranoside () from the whole plant of collected in Vietnam. The chemical structures were determined by HRESIMS, 1D- and 2D-NMR analysis, and comparison with published data. Compound exhibited potent cytotoxicity against MCF7, HepG2, SK-LU-1, and HT-29 human cancer cell lines with IC values ranging from 0.

Structure revision and absolute configuration of 5,7--hydroxyoplopanone and anti-osteoporotic activities of sesquiterpenoids from the rhizomes of .

Five sesquiterpenoids including 2-hydroxyoplopanone , oplopanone (), 1,4,6-trihydroxy-eudesmane (), 1,4,7-trihydroxy-eudesmane () and bullatantriol () were isolated from . The structure of the previously reported compound, 5,7--2-hydroxyoplopanone (), has been revised to by the spectroscopic evidences (1D-/2D-NMR, IR, UV and HRESIMS) and by comparison between experimental and theoretical NMR data using DP4+ protocol. Furthermore, the absolute configuration of was unambiguously assigned by ECD experiments.

Aspiletrein A Induces Apoptosis Cell Death via Increasing Reactive Oxygen Species Generation and AMPK Activation in Non-Small-Cell Lung Cancer Cells.

Lung cancer remains a leading cause of death in cancer patients, and deregulation of apoptosis is a serious concern in clinical practice, even though therapeutic intervention has been greatly improved. Plants are a versatile source of biologically active compounds for anticancer drug discovery, and aspiletrein A (AA) is a steroidal saponin isolated from that has a potent cytotoxic effect on various cancer cell lines. In this study, we investigated and determined the underlying molecular mechanism by which AA induces apoptosis.

Homalolides C-D, two new sesquiterpenoids from the rhizomes of .

Two new sesquiterpenoids, homalolides C - D ‒, were co-isolated from the rhizomes of (Blume) Bakh.f collected in Vietnam with five known ones, aromadendrane-4,10-diol (), bullatantriol (), 1,4,6-trihydroxy-eudesmane (), 1,4,6-trihydroxyeudesmane (), and 1,4,7-trihydroxy-eudesmane (). The structures and relative configuration of new compounds were elucidated by 1 D-/2D-NMR, IR, UV and HRESIMS analyses, and by comparisons to the reported data in the literature.

A new spirostanol steroid and a new spirostanol steroidal saponin from and their cytotoxic activities.

A new spirostanol steroid, aspidiata A (), and a new spirostanol steroidal saponin, aspidiata B (), along with three known compounds, paris saponin VII (), daucosterol (), and (25)-spirostane-1,2,3,4,5,6-hexol (), were isolated from whole plants of collected in Vietnam. Their chemical structures were established by spectroscopic analysis and comparison with previously published data. Compound showed strong cytotoxicity against LU-1, Hep-G2, MCF-7, and KB human cancer cell lines with half maximal inhibitory concentration (IC) values ranging from 0.

Antioxidant activity and -glucosidase inhibitability of M.F. Newman rhizome fractionated extracts: in vitro and screenings.

Unlabelled: M.F. Newman (commonly known as "Black Ginger") is an endemic plant to Vietnam and has been extensively exploited by folk medication for treatments of infection-related diseases and diabetes.

Sesquiterpenoids from the rhizomes of and their anti-inflammatory activities.

Sixteen sesquiterpenoids including two new ones, homalolides A - B ‒, were firstly isolated from the methanolic extract of the rhizomes of collected in Vietnam. The structures and relative stereochemistry of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses. The GCMS experiment demonstrated that homalolide A () is an artifact due to the methylation during methanolic extraction process.

Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells.

Background: Lung cancer is one of the leading causes of death worldwide due to its strong proliferative and metastatic capabilities. The suppression of these aggressive behaviors is of interest in anticancer drug research and discovery. In recent years, many plants have been explored in order to discover new bioactive secondary metabolites to treat cancers or enhance treatment efficiency.

Antioxidant Activity of a New Xanthone Derivative from Aspidistra Letreae: In Vitro and In Silico Studies.

A new xanthone derivative, aspidxanthone A (1), and three known compounds ((2S)-1-(β-D-galactopyranosyloxy)-3-(hexadecanoyloxy)propan-2-yl (9Z,12Z)-octadeca-9,12-dienoate (2), (25S)-spirostane-1β,3α,5β-triol (3), and asparenyldiol (4)) were isolated from the whole of the endemic species Aspidistra letreae in Vietnam. Their structures were elucidated by means of extensive spectroscopic analyses and comparison with published data. In this study, we report the isolation and structure elucidation of a new compound aspidxanthone A, antioxidant activities of the extract and isolates 1-4, and in silico molecular docking of aspidxanthone A.

Flavonoids and alkaloids from the rhizomes of Zephyranthes ajax Hort. and their cytotoxicity.

A new flavanol derivative, (2R,3R)-3-acetoxy-7-hydroxy-3',4'-methylenedioxyflavan (1), was co-isolated from the rhizomes of Zephyranthes ajax Hort. with the following seven known compounds: 7-hydroxyflavan (2), 7,4'-dihydroxyflavan (3), 7,4'-dihydroxy-8-methylflavan (4), 7,3'-dihydroxy-4'-methoxyflavan (5), 5,4'-dihydroxy-7-methoxy-6-methylflavan (6), 7-hydroxy-3',4'-methylenedioxyflavanone (7) and haemanthamine (8). Their structures were elucidated by combining 1D-/2D-NMR, CD, UV and HRESIMS data, and comparisons with reported data in literature were made.

Effects of on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer's disease.

Context: The methanol extracts from (L'Hér.) Herb. (Amaryllidaceae) (HR) display acetylcholinesterase inhibitory (AChEI) activity.