Two New Myrsinane-type Diterpenoids From the Aerial Parts of Jatropha integerrima Jacq. and Their Antimicrobial Activity.

In the search for new antimicrobial agents, this study investigated the phytochemical composition of the aerial parts of Jatropha integerrima, leading to the isolation of two new myrsinane-type diterpenoids, jatrophodiones F and G (1, 2), along with seven known compounds: jatrointelone A (3), α-tocospiro A (4), 8(14),15-sandaracopimaradien-3β-ol (5), curdione (6), 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (7), 7-oxo-β-sitosterol (8), and 3β-hydroxystigmast-5(6),22-diene-7-one (9). The structures of these compounds were elucidated via high-resolution electrospray ionization time-of-flight mass spectrometry and infrared, ultraviolet, and nuclear magnetic resonance spectroscopy, comparing the analyses with reported spectroscopic data. Compounds 1-3 and 5-9 exhibited moderate to strong activity against eight microorganisms, including Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, Staphylococcus aureus, Candida albicans, and Aspergillus brasiliensis, with minimum inhibitory concentrations (MICs) ranging from 32 to 256 µg/mL.

and Antimicrobial Activity against Methicillin-Resistant of Essential Oils from Four Medicinal Plants in Xuan Thuy Mangrove Forest.

, , , and are medicinal plants found in Xuan Thuy mangrove forest that contain essential oils (EOs) and the potential to treat infections. The obtained yields of hydrodistillation essential oil from aerial parts and leaves ranged from 0.01% to 0.

A new 14-membered cembrane-type diterpenoid and other constituents from the aerial parts of Jacq. and their antibacterial activity.

A new 14-membered cembrane- diterpenoid, jatrophainolide D (), along with six known compounds, ()-phytol (), lupeol (), stigmasterol (), ergosta-4,6,8 (14),22-tetraen-3-one (), stigmast-4-ene-3-one (), and ergosterol peroxide () were isolated from the aerial parts of . The structure of isolates was elucidated by IR, UV, 1D-/2D-NMR, and HRESI-TOFMS data as well as by comparison with the reported spectroscopic data. All isolates were evaluated the antibacterial activity against , , , , , and .

Secondary metabolites from marine fungus Penicillium chrysogenum VH17 and their antimicrobial and cytotoxic potential.

One new compound, methyl 3-((1-((2-carbamoylphenyl)amino)-1-oxopropan-2-yl)amino)-3-oxopropanoate (1), along with 9 known secondary metabolites (2-10) were isolated and elucidated chemical structures from the methanol extract of the marine-derived fungus Penicillium chrysogenum VH17. Subsequent bioassays showed the antimicrobial and cytotoxic potential of the isolated compounds. All compounds 1-10 displayed antimicrobial effects against at least one tested reference microorganism with MIC values ranging from 32 to 256 µg mL-1.

Antimicrobial and Cytotoxic Secondary Metabolites from a Marine-Derived Fungus Penicillium Citrinum VM6.

Investigation of an antimicrobial and cytotoxic ethyl acetate extract prepared from solid fermentation of the marine-derived fungus Penicillium citrinum VM6 led to the isolation of eight metabolites (1-8), including one citrinin dimer dicitrinone F (1). Of these, compound 7 was isolated for the first time from the Penicillium genus and compound 1 with carbon-bridged C-7/C-7' linkage is rarely reported. All compounds (1-8) exhibited selective antimicrobial activity against the tested Gram-positive bacteria and Candida albicans with MICs of 32-256 µg/mL.

Identification of potential anti-hyperglycemic compounds in ethyl acetate extract: and studies.

has been long known for valuable health benefits by folk experience and was recently reported with diabetes-tackling evidences, thus deserving extending efforts on screening for component-activity relationship. In this study, experiments were carried out to find the evidence, justification, and input for computations on the potential against diabetes-related protein structures: PDB-4W93, PDB-3W37, and PDB-4A3A. Liquid chromatography identified 14 bioactive compounds in the ethyl acetate extract (-) and quantified the contents of cordycepin (0.

Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from : and in silico studies.

Introduction: is a species of herb used as a popular food in Vietnam. Furthermore, the species has been used as a Vietnamese traditional medicine to treat many diseases.

Methods: Chemical constituents in the essential oil from leaves of were determined using GC/MS analysis.

Identification of potential inhibitors against Alzheimer-related proteins in ethanol extract: experimental evidence and computational analyses.

Unlabelled: Laboratory experiments were carried out to identify the chemical composition of and reveal the first evidence of their Alzheimer-related potential. Liquid chromatography-mass spectrometry analysis identified 21 bioactive compounds in the ethanol extract (). High-performance liquid chromatography quantified the content of cordycepin (0.

Diversity of Bacterial Secondary Metabolite Biosynthetic Gene Clusters in Three Vietnamese Sponges.

Recent reviews have reinforced sponge-associated bacteria as a valuable source of structurally diverse secondary metabolites with potent biological properties, which makes these microbial communities promising sources of new drug candidates. However, the overall diversity of secondary metabolite biosynthetic potential present in bacteria is difficult to access due to the fact that the majority of bacteria are not readily cultured in the laboratory. Thus, use of cultivation-independent approaches may allow accessing "silent" and "cryptic" secondary metabolite biosynthetic gene clusters present in bacteria that cannot yet be cultured.

Correlating biodegradation kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the dynamics of microbial communities originating from soil in Vietnam contaminated with herbicides and dioxins.

We studied the succession of bacterial communities during the biodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The communities originated from a mesocosm with soil from Bien Hoa airbase in Vietnam heavily contaminated with herbicides and dioxins. They were grown in defined media with different carbon and Gibbs energy sources and 2,3,7,8-TCDD.

Pharmacological Properties, Volatile Organic Compounds, and Genome Sequences of Bacterial Endophytes from the Mangrove Plant Blume.

Mangrove plant endophytic bacteria are prolific sources of bioactive secondary metabolites. In the present study, twenty-three endophytic bacteria were isolated from the fresh roots of the mangrove plant . The identification of isolates by 16S rRNA gene sequences revealed that the isolated endophytic bacteria belonged to nine genera, including , , , , , , , , and .

Bacteria Cultivated From Sponges and Bacteria Not Yet Cultivated From Sponges-A Review.

The application of high-throughput microbial community profiling as well as "omics" approaches unveiled high diversity and host-specificity of bacteria associated with marine sponges, which are renowned for their wide range of bioactive natural products. However, exploration and exploitation of bioactive compounds from sponge-associated bacteria have been limited because the majority of the bacteria remains recalcitrant to cultivation. In this review, we (i) discuss recent/novel cultivation techniques that have been used to isolate sponge-associated bacteria, (ii) provide an overview of bacteria isolated from sponges until 2017 and the associated culture conditions and identify the bacteria not yet cultured from sponges, and (iii) outline promising cultivation strategies for cultivating the uncultivated majority of bacteria from sponges in the future.

Diversity and Antimicrobial Activity of Vietnamese Sponge-Associated Bacteria.

This study aimed to assess the diversity and antimicrobial activity of cultivable bacteria associated with Vietnamese sponges. In total, 460 bacterial isolates were obtained from 18 marine sponges. Of these, 58.

A new steroidal saponin from the aerial parts of .

A new steroidal saponin, torvoside R (), was isolated along with torvoside Q () and macaoside () from dichloromethane soluble-portion of the aerial parts of . Their chemical structures were elucidated using HRESIMS, 1 D- and 2 D-NMR as well as comparison with those reported in the literature. All isolated compounds (-) exhibited cytotoxicity against SK-LU-1, HepG2, MCF-7, and T24 cancer cell lines with IC values ranging from 14.

Cytotoxic activity of steroidal glycosides from the aerial parts of collected in Thua Thien Hue, Vietnam.

A phytochemical investigation of led to the isolation of eleven steroidal glycosides, including neochlorogenin 6---D-quinovopyranoside (), (22 ,23,25)-3-6,23-trihydroxy-5-spirostane 6---D-xylopyranosyl-(1→3)--D-quinovopyranoside (), neochlorogenin 6---L-rhamnopyranosyl-(1→3)--D-quinovopyranoside (), solagenin 6---L-rhamnopyranosyl-(1→3)--D-quinovopyranoside (), paniculonin A (), paniculonin B (), 6α--[-D-xylopyranosyl-(1→3)-D-quinovopyranosyl]-(25)-5α-spirostan-3-ol (), torvoside J (), torvoside K (), torvoside L () and solagenin 6---D-quinovopyranoside (). Their chemical structures were elucidated by 1D-NMR and 2D-NMR data as well as comparison with the data reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against SK-LU-1, HepG2, MCF-7 and T24 cancer cell lines.

Cytotoxic and anti-inflammatory activities of secondary metabolites from growing in Thua Thien Hue, Vietnam.

A new ursane-type triterpene, 3,23,24-trihydroxyurs-12-en-28-oic acid (), together with eight known compounds (-) were isolated from the aerial parts of . Among them, compounds - were found for the first time from the genus , while compounds - were reported from for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR (H-NMR, C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature.

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products.

Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral and its associated microorganisms are promising providers of marine bioactive compounds. The present review provides an overview of bioactive compounds that are produced by corals and coral-associated microorganisms, covering the literature from 2010 to March 2019.

Identification Of Potential Cytotoxic Inhibitors From .

A phytochemical investigation of led to the isolation of six withanolides, including withanolide E (), withaperuvin C (), 4-hydroxywithanolide E (), 28-hydroxywithaperuvin C (), physaperuvin G (), and 4-deoxywithaperuvin (). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines.

study on α-amylase and α-glucosidase inhibitory activities of a new stigmastane-type steroid saponin from the leaves of .

Using various chromatographic separations, four compounds, including one new steroid saponin named vernoamyoside E (), were isolated from the leaves of the Vietnamese medicinal plant Delile (Asteraceae). Their structures were established by spectroscopic methods such as 1D- and 2D-NMR, HR-ESI-MS, and HPLC analysis. The inhibitory activities against α-glucosidase and α-amylase of the isolated compounds from were reported for the first time.

Archaeal and bacterial diversity and community composition from 18 phylogenetically divergent sponge species in Vietnam.

Sponge-associated prokaryotic diversity has been studied from a wide range of marine environments across the globe. However, for certain regions, e.g.