Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The effectiveness of lesion formation during cryoballoon ablation (CBA) may be influenced by the extent of acute local inflammation induced during the ablation process. This study aims to evaluate the predictive value of inflammatory markers following CBA.
Methods: A total of 102 consecutive patients with paroxysmal atrial fibrillation (AF) who underwent CBA (51.9% male; mean age 56.7 ± 11.5 years) were prospectively included in the study. Blood samples for Systemic Immune-Inflammation Index (SII), C-reactive protein (CRP), lymphocyte counts (LC) were collected from all participants prior to, and within 24 h post-procedure. SII was calculated as platelet count × neutrophil count / lymphocyte count. 12-lead electrocardiograms, clinical evaluations, medical history reviews, and 24-hour Holter monitoring were performed at one, three-, and six-months post-ablation. Recurrences of AF occurring beyond the initial 30-day blanking period were documented and analyzed.
Results: Over a mean follow-up period of 12.3 ± 5.1 months, AF recurrence was observed in 30 (29.4%) patients. SII, CRP, LC, and left atrial end-systolic diameter (LAD), were associated with AF recurrence. Multivariable Cox regression analysis identified post-ablation SII levels as the sole independent predictor of AF recurrence (hazard ratio [HR]: 0.139; 95% confidence interval [CI]: 0.052-0.369; p < 0.001). Receiver operating characteristic (ROC) curve analysis determined an SII cut-off value of 900 for predicting AF recurrence, yielding a sensitivity of 80.0% and specificity of 63.9%. The area under the curve (AUC) was 0.72 (p < 0.001).
Conclusion: Lower post-ablation levels of SII predict AF recurrence following CBA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10840-025-02071-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of inflammatory index with the severity of disease in patients with acute myocarditis: A retrospective observational study.
Front Endocrinol (Lausanne)
September 2025
Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, China.
Purpose: This research aimed to investigate the association between neutrophil-percentage-to-albumin ratio (NPAR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) with disease severity in patients diagnosed with acute myocarditis.
Methods: A total of 185 patients were diagnosed with acute myocarditis at the First Hospital of Jilin University between 2018 and 2024. The related values of NPAR, SII, SIRI, and AISI were computed based on the pertinent blood indices that were acquired within 12 hours of admission.
The Systemic Immune-Inflammation Index Predicts Long-Term Outcomes in Patients With Unstable Angina and Diabetes After Revascularization.
Rev Cardiovasc Med
August 2025
Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, 100029 Beijing, China.
Background: The incidence of unstable angina (UA), a type of cardiovascular disease (CVD), has increased in recent years. Meanwhile, timely percutaneous coronary intervention (PCI) or percutaneous transluminal coronary angioplasty (PTCA) procedures are crucial for patients with UA who also have diabetes mellitus (DM). Additionally, exploring other factors that may influence the prognosis of these patients could provide long-term benefits.
View Article and Find Full Text PDFThe Pretreatment Neutrophil-to-Eosinophil Ratio Can Predict Immune-Related Adverse Events and Outcomes in Patients With Advanced Urothelial Carcinoma Treated With Immune Checkpoint Inhibitors.
Cureus
August 2025
Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, JPN.
Introduction Currently, treatment regimens incorporating immune checkpoint inhibitors (ICIs) are the standard of care for locally advanced or metastatic urothelial carcinoma (la/mUC). This study aimed to investigate the association between the neutrophil-to-eosinophil ratio (NER) and the occurrence of immune-related adverse events (irAEs) as well as treatment outcomes. Methods This multicenter retrospective study examined patients with la/mUC treated with ICIs between January 2017 and December 2022.
View Article and Find Full Text PDFDiagnostic and prognostic value of systemic immune-inflammation index for heart failure: a systematic review and meta-analysis.
Front Cardiovasc Med
August 2025
Traditional Chinese Medicine Department, The Eighth Affiliated Hospital, Sun Yat-sen University (FuTian, Shenzhen), Shenzhen, Guangdong, China.
Background: Increasing evidence has indicated the potential correlation between Systemic Immune-Inflammation Index (SII) and the incidence and prognosis of patients with heart failure (HF). However, the association remains unraveled in the existing research.
Methods: A literature search was systematically conducted across PubMed, Embase, Web of Science, and the Cochrane Library from their respective inceptions to July 2024, aiming to identify studies investigating the association between SII and both the incidence and clinical outcomes of HF patients.
Background: Based on the widespread use of the systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), markers, we aimed to calculate and compare the reference intervals (RIs) of these indices in adults, using both nonparametric method according to the Clinical and Laboratory Standards Institute's (CLSI) EP28-A3C:2010 guideline and refineR algorithm using a large dataset.
Methods: We analyzed data from 293,585 adults (18 - 65 years) retrospectively obtained from complete blood count results (using laboratory information system). The study involved a two-stage outlier exclusion process.