98%
921
2 minutes
20
Background: Older adults have a high probability of experiencing falls during activities of daily living, which can lead to fear of falling, alterations in gait patterns, decreased mobility, reduced social interactions, and limited ability to perform various tasks. Previous studies examining gait in the presence of perturbations have identified and analyzed several protective gait strategies aimed at preventing falls. However, there is a lack of standardized terminology and definitions for these strategies, hindering comparison and collaborative progress among researchers and professionals.
Objective: To unify definitions of compensatory protective step strategies and establish a standardized terminology.
Methods: This study adapted the Conducting and Reporting of Delphi Studies (CREDES) guidelines and followed a chronological sequence: 1) Preliminary phase: A literature review and both quantitative (three dimensions: relevance, wording, and identification, assessed using a Likert-type scale (1 to 5) and qualitative (an open-ended question) assessment were conducted; 2) Exploratory phase: Expert panel selection (n = 14) and the e-Delphi study were conducted; and 3) Final phase: Expert opinions were collected and analyzed. Content validity was assessed using Aiken's V coefficient.
Results: The results demonstrated high levels of validity (V ≥ 0.68) for all definitions, with none being eliminated based on Aiken's V critical value.
Conclusion: A precise definition was developed for each of the 14 compensatory protective step strategies (13 identified in the scoping review and one added by the expert panel). In total, the number of definitions was reduced from 61 to 14, with one definition for each of the compensatory protective step strategies identified.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148634 | PMC |
http://dx.doi.org/10.1016/j.bjpt.2025.101227 | DOI Listing |
Problem: The postpartum period is associated with low physical activity, and increased risk of activity-related adverse health conditions.
Background: Urinary incontinence (UI) is a prevalent postpartum condition associated with low physical activity which protects against many adverse postpartum health conditions. However, little is known about how postpartum women experience UI and physical activity.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. Disruptions in iron metabolism and mitochondrial oxidative function may cooperatively contribute to its pathogenesis. Ferredoxin reductase (FDXR), a mitochondrial flavoprotein, plays a critical role in mitochondrial respiratory supercomplex formation and iron-sulfur cluster biosynthesis-both essential for efficient oxidative metabolism.
View Article and Find Full Text PDFThe complex relationship between the gut microbiome and immune system development during infancy is thought to be a key factor in the rising rates of pediatric allergic diseases. Food protein-induced allergic proctocolitis (AP), the earliest identified form of non-IgE-mediated food allergy in infants, occurs at the mucosal surface where dietary proteins, intestinal microbes, and immune cells directly interact, and increases the risk for life threatening IgE-mediated food allergy, making it an important model for understanding early food allergic disease development. The question of how specific microbial compositions and functional pathways contribute to AP development and progression remains poorly understood.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Cardiology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Ischemia-reperfusion injury, marked by transient blood flow disruption followed by tissue reperfusion, constitutes a unifying pathological mechanism across cerebral stroke, myocardial infarction, and acute kidney injury. Hypoxia, a central driver of ischemia-reperfusion injury progression, triggers molecular cascades that simultaneously exacerbate tissue damage and activate compensatory repair mechanisms. Notably, hypoxia-induced angiogenesis and vascular remodeling serve as critical adaptive processes for functional recovery, supporting neuronal plasticity in stroke, myocardial salvage in infarction, and tubular regeneration in renal ischemia-reperfusion injury.
View Article and Find Full Text PDFCell Death Differ
September 2025
Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan.
Nucleotide metabolism is essential for fundamental cellular functions such as growth, repair and proliferation. Emerging evidence suggests that metabolic pathways also influence programmed cell death (PCD), though the underlying mechanisms remain poorly understood. One model organism that has provided key insights into the regulation of PCD is Caenorhabditis elegans (C.
View Article and Find Full Text PDF