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Article Abstract
Purpose: To establish and optimize abdominal deuterium MR spectroscopic imaging in conjunction with orally administered H-labeled molecules.
Methods: A flexible transmit-receive surface coil was used to image naturally abundant deuterium signal in phantoms and healthy volunteers and after orally administered HO in a patient with a benign renal tumor (oncocytoma).
Results: Water and lipid peaks were fitted with high confidence from both unlocalized spectra and from voxels within the liver, kidney, and spleen on spectroscopic imaging. Artifacts were minimal, despite the high HO concentration in the stomach immediately after ingestion, which can be problematic with the use of a volume coil.
Conclusion: We have shown the feasibility of abdominal deuterium MR spectroscopic imaging at 3 T using a flexible surface coil. Water measurements were obtained in healthy volunteers, and images were acquired in a patient with a renal tumor after drinking HO. The limited depth penetration of the surface coil may have advantages in characterizing early uptake of orally administered agents in abdominal organs, despite the high concentrations in the stomach which can pose challenges with other coil combinations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309867 | PMC |
| http://dx.doi.org/10.1002/mrm.30556 | DOI Listing |
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