Development and optimization of human deuterium MR spectroscopic imaging at 3 T in the abdomen.

Purpose: To establish and optimize abdominal deuterium MR spectroscopic imaging in conjunction with orally administered H-labeled molecules.

Methods: A flexible transmit-receive surface coil was used to image naturally abundant deuterium signal in phantoms and healthy volunteers and after orally administered HO in a patient with a benign renal tumor (oncocytoma).

Results: Water and lipid peaks were fitted with high confidence from both unlocalized spectra and from voxels within the liver, kidney, and spleen on spectroscopic imaging.

A pathway toward clinical translation of hyperpolarized [1,4-C,2,3-d]fumarate as an imaging biomarker for early cellular necrosis in vivo.

Purpose: The detection of hyperpolarized carbon-13 (HP C)-fumarate conversion to C-malate using C-MRSI is a biomarker for early detection of cellular necrosis. Here, we describe the translation of HP C-fumarate as a novel human imaging agent, including the evaluation of biocompatibility and scaling up of the hyperpolarization methods for clinical use.

Methods: Preclinical biological validation was undertaken in fumarate hydratase-deficient murine tumor models and controls.

Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field Strength.

Objectives: The aim of the study was to translate abdominal deuterium metabolic imaging (DMI) to clinical field strength by optimizing the radiofrequency coil setup, the administered dose of deuterium (2H)-labeled glucose, and the data processing pipeline for quantitative characterization of DMI signals over time. This was assessed in the kidney and liver to establish a basis for routine clinical studies in the future.

Materials And Methods: 5 healthy volunteers were recruited and imaged on 2 or 3 separate occasions, with varying doses of 2H-glucose: 0.

SABRE-SHEATH Hyperpolarization of [1,5-C]Z-OMPD for Noninvasive pH Sensing.

Hyperpolarized (HP) C-labeled probes are emerging as promising agents to noninvasively image pH in vivo. HP [1,5-C]Z-OMPD (Z-4-methyl-2-oxopent-3-enedioic acid) in particular has recently been used to simultaneously report on kidney perfusion, filtration, and pH homeostasis, in addition to the ability to detect local tumor acidification. In previous studies, dissolution dynamic nuclear polarization was used to hyperpolarize Z-OMPD.

Quo Vadis Hyperpolarized C MRI?

Over the last two decades, hyperpolarized C MRI has gained significance in both preclinical and clinical studies, hereby relying on technologies like PHIP-SAH (ParaHydrogen-Induced Polarization-Side Arm Hydrogenation), SABRE (Signal Amplification by Reversible Exchange), and dDNP (dissolution Dynamic Nuclear Polarization), with dDNP being applied in humans. A clinical dDNP polarizer has enabled studies across 24 sites, despite challenges like high cost and slow polarization. Parahydrogen-based techniques like SABRE and PHIP offer faster, more cost-efficient alternatives but require molecule-specific optimization.

Hyperpolarised C-MRI using C-pyruvate in breast cancer: A review.

Tumour metabolism can be imaged with a novel imaging technique termed hyperpolarised carbon-13 (C)-MRI using probes, i.e., endogenously found molecules that are labeled with C.

Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized C-labelled Z-OMPD.

pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-C]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerprint of renal disease status and to detect local tumor acidification. Exceptional long T of two minutes at 1 T, high pH sensitivity of up to 1.