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This is a rare case of Candida onychomycosis caused by three Candida species that were resistant to several antifungal drugs. A 56-year-old Iranian woman with no previous medical or injury history experienced discoloration and lifting of her left thumbnail for six months. Laboratory tests identified yeast and pseudohyphae consistent with Candida onychomycosis. Conventional and molecular techniques confirmed that onychomycosis was caused by three different Candida species. All strains were resistant to various antifungal drugs. Therapeutic failure, in addition to multi-drug resistance, may be due to the presence of multiple etiological agents.
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http://dx.doi.org/10.1016/j.ijmmb.2025.100870 | DOI Listing |
Life (Basel)
August 2025
Mediprobe Research Inc., London, ON N5X 2P1, Canada.
Onychomycosis is a prevalent and clinically relevant complication among individuals with diabetes. It is associated with an elevated risk of secondary fungal and bacterial infections, foot ulceration, and, in advanced cases, amputation. Factors contributing to the increased prevalence of onychomycosis in this population include age, peripheral vascular disease, poor glycemic control, neuropathy, suboptimal foot hygiene, and nail trauma.
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August 2025
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Candida onychomycosis is a common fungal nail infection where treatment efficacy can be compromised by antifungal resistance. This study investigates the role of efflux pump genes (CDR1, CDR2, and MDR1) and biofilm-associated genes (ALS1, ALS3) in Candida albicans isolates classified as resistant to itraconazole from patients with onychomycosis. Ten itraconazole-resistant and 10 sensitive isolates were collected for efflux pump and biofilm-associated gene expression analysis by Real-Time PCR methods.
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September 2025
Albert Einstein College of Medicine, Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Bronx, New York 10461, United States.
Onychomycosis is one of the most prevalent fungal infections worldwide, resulting in negative effects on general quality of life. Management of the disease encounters a series of obstacles, and antifungal treatment has a low success rate. We aimed to develop and evaluate a novel formulation of NO-releasing microparticles (SNO-MPs) against some of the most common causative agents of onychomycosis: , , , and .
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January 2025
Section of Dermatology, Department of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.
Here we describe the case reports of three patients, 35, 64, and 72 year old, respectively, who were presented to the dermatology clinic for suspected onychomycosis with discolored and hardened nails. Both light microscopic analysis of the samples taken and culture analysis on SDA and DTM media were carried out. Direct microscopic analysis revealed the presence of yeast cells in the interstitial space of keratinocytes.
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July 2025
Hue City Hospital of Dermatology and Venereology, Huong An commune, 4900 Hue City, Vietnam.
The Candida parapsilosis complex, consisting of C. parapsilosis sensu stricto, C. orthopsilosis, and C.
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