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Clinical Document Classification (CDC) is crucial in healthcare for organizing and categorizing large volumes of medical information, leading to improved patient care, streamlined research, and enhanced administrative efficiency. With the advancement of artificial intelligence, automatic CDC is now achievable through deep learning techniques. While existing research has shown promising results, more effective and accurate classification of long clinical documents is still desired. To address this, we propose a new model called the Enhanced Effective Convolutional Attention Network (EECAN), which incorporates a Squeeze-and-Excitation (SE) Inception module to improve feature representation by adaptively recalibrating channel-wise feature responses. This architecture introduces an Encoder and Attention-Based Clinical Document Classification (EAB-CDC) strategy, which utilizes sum-pooling and multi-layer attention mechanisms to extract salient features from clinical document representations. This study proposes EECAN (Enhanced Effective Convolutional Attention Network) as the overall model architecture and EAB-CDC (Encoder and Attention-Based Clinical Document Classification) as a core strategy conducted in EECAN. EAB-CDC is not a standalone model but a functional part applied to the architecture for discriminative feature extraction by sum-pooling and multi-layer attention mechanisms. With this integrated design, EECAN can transform multi-label clinical texts' general and label-specific contexts without losing information. Our empirical study, conducted on benchmark datasets such as MIMIC-III and MIMIC-III-50, demonstrates that the proposed EECAN model outperforms several existing deep learning approaches, achieving AUC scores of 99.70% and 99.80% using sum-pooling and multi-layer attention, respectively. These results highlight the model's substantial potential for integration into clinical systems, such as Electronic Health Record (EHR) platforms, for the automated classification of clinical texts and improved healthcare decision-making support.
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http://dx.doi.org/10.1038/s41598-025-98719-0 | DOI Listing |
Curr Med Sci
September 2025
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective: To develop a novel prognostic scoring system for severe cytokine release syndrome (CRS) in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 chimeric antigen receptor (CAR)-T-cell therapy, aiming to optimize risk mitigation strategies and improve clinical management.
Methods: This single-center retrospective cohort study included 125 B-ALL patients who received anti-CD19 CAR-T-cell therapy from January 2017 to October 2023. These cases were selected from a cohort of over 500 treated patients on the basis of the availability of comprehensive baseline data, documented CRS grading, and at least 3 months of follow-up.
Probiotics Antimicrob Proteins
September 2025
Operational Research Centre in Healthcare, Near East University, Nicosia, Cyprus.
Probiotics are live beneficial microorganisms that confer health benefits to the host when administered in adequate amounts, have gained considerable scientific and commercial interest for their ability to support gut health, strengthen immunity, and reduce disease risk. This review traces the genesis of probiotic science from its origins in traditional fermented foods to contemporary clinical applications, offering a conceptual understanding of its evolution. A clear distinction is drawn between endogenous probiotics, naturally resident in the human microbiome, and exogenous probiotics, introduced via dietary supplements and functional foods.
View Article and Find Full Text PDFAdv Health Sci Educ Theory Pract
September 2025
Division of Human Sciences, NOSM University, Thunder Bay, ON, Canada.
Innovative qualitative approaches are essential for exploring how health professions education (HPE) can address complex, value-laden constructs such as social accountability. Visual elicitation techniques, including rich picture interviews (RPIs), offer distinctive opportunities to surface layered, affective, and contextually embedded understandings. This methodological study examines participant perspectives on the use of RPIs within a broader qualitative interpretive description on social accountability.
View Article and Find Full Text PDFDrugs Aging
September 2025
Dalla Lana School of Public Health, University of Toronto, V1 06, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Background And Objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that rely on unlabeled data-that is, where the algorithm itself is discovering patterns without the need for researchers to label the data with a known outcome. These methods may help us to better understand complex prescribing patterns in this population.
View Article and Find Full Text PDF