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BackgroundEvidence-informed decision-making in public health (PH) is a complex process requiring the consideration of multiple perspectives and contextual factors. Evidence-to-decision (EtD) frameworks are structured approaches aiming to improve decision-making by considering critical criteria, but users' experience has not been systematically synthesised.AimWe aim to summarise users' experiences of EtD frameworks used for PH.MethodsAs part of a broader scoping review, we identified 15 EtD frameworks for PH decision-making. We searched MEDLINE and Health Systems Evidence, conducted a hand search and citation search strategy for documents reporting users' experience of EtD frameworks and surveyed key stakeholders. We conducted a descriptive thematic synthesis, identifying main barriers and facilitators, complementing with surveys to relevant stakeholders.ResultsWe identified 12 studies reporting users' experience of two EtD frameworks: Grading of Recommendations Assessment, Development and Evaluation (n = 9) and World Health Organization INTEGRATe Evidence (n = 3). Both were perceived as structured approaches that enhanced the use of evidence while including contextual factors and facilitating consensus-building processes. Main barriers were lack of high-quality evidence for the effectiveness of PH interventions, limitations of the terminology or unclear boundaries between specific criteria, perceptions of missing criteria and the need for more guidance. Survey responses (n = 13) were consistent with these findings.ConclusionUsers of the two frameworks had an overall positive perception of the approaches, but several barriers remain. These experiences may change over time as the frameworks evolve. There is an evidence gap regarding users' experience for other EtD frameworks.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083067 | PMC |
http://dx.doi.org/10.2807/1560-7917.ES.2025.30.19.2400184 | DOI Listing |
J Vis Exp
August 2025
Marianne Bernadotte Centrum, Department for Clinical Neuroscience, Karolinska Institutet; St Erik Eye Hospital.
The present protocol evaluates the relative impact of visual and vestibular inputs during roll plane rotations using optokinetic, vestibular, and combined visuovestibular stimulations. Subjects underwent isolated visual rotations, whole-body vestibular rotations in darkness, and visuovestibular stimulations combining static visual scenes with head rotations. Dynamic and static eye movement gains, absolute amplitudes, velocities, and accelerations were measured alongside perceptual responses.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
Forensic Sci Int
August 2025
College of Electrical and Information Engineering, Hunan University, Yuelu District, Changsha, Hunan 410082, China. Electronic address:
Extracting the electric network frequency (ENF) from digital audio signals is a crucial means of forensic evidence. However, ENF signal extraction is susceptible to noise, making it challenging to establish a reliable matching relationship with the reference frequency database, especially under low signal-to-noise ratio (SNR) conditions. To solve this problem, an ENF extraction and tampering detection framework (ENF-ETD) for low SNR conditions is proposed in this article.
View Article and Find Full Text PDFAlzheimers Dement
July 2025
Alzheimer's Association, Chicago, Illinois, USA.
Objective And Scope: A panel of clinicians, subject-matter experts, and guideline methodologists convened by the Alzheimer's Association conducted a systematic review and formulated evidence-based recommendations for using blood-based biomarkers (BBMs) in the diagnostic workup of suspected Alzheimer's disease (AD) within specialized care settings. The scope focuses on individuals with objective cognitive impairment, including those with mild cognitive impairment (MCI) or dementia, who are undergoing evaluation by providers trained and experienced in memory disorders, where AD is the suspected underlying etiology.
Methods: The panel conducted a systematic review to assess the diagnostic accuracy of BBMs in detecting AD pathology.
J Clin Endocrinol Metab
August 2025
Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Background: Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a common cause of hypertension. It is associated with an increased risk of cardiovascular complications compared with primary hypertension. Despite effective methods for diagnosing and treating PA, it remains markedly underdiagnosed and undertreated.
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