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http://dx.doi.org/10.1002/jmv.70401 | DOI Listing |
Annu Rev Pathol
September 2025
3Department of Pathology, Stanford University, Stanford, California, USA;
Clonal hematopoiesis, originally identified as a precursor to hematologic malignancies, has emerged as a significant factor in various nonmalignant diseases. Recent research highlights how somatic mutations in hematopoietic stem cells lead to the expansion of circulating mutated immune cells that exert profound effects on organ function and disease progression. These mutated clones display altered inflammatory profiles and tissue-specific functional consequences, contributing to various diseases including atherosclerotic cardiovascular disease, osteoporosis, heart failure, and neurodegenerative conditions.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34051, Republic of Korea.
Microscopic examination of biopsy tissues remains essential for cancer diagnosis, despite advancements in sequencing technologies. Alterations in nuclear size or the nuclear-to-cytoplasmic ratio are hallmark features of cancer cells and often correlate with disease progression. However, the mechanisms underlying nuclear size abnormalities and their impact on tumor progression remain unclear.
View Article and Find Full Text PDFACS Sens
September 2025
Department of Electrical and Computer Engineering, Inha University, Incheon 22212, Republic of Korea.
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia with multiple clinical manifestations and complications, such as cardiovascular disease, kidney dysfunction, retinal impairment, and peripheral neuropathy. Continuous and minimally invasive glucose monitoring is essential for effective DM management. Microneedles (MNs)-based sensing platforms offer a promising solution; however, conventional polymeric MNs suffer from limited electrochemical sensitivity due to their insufficient electroactive surface area and inefficient loading of catalytic and enzymatic components.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Shock Wave Research Laboratory, Department of Physics, Abdul Kalam Research Center, Sacred Heart College (Autonomous), affiliated to Thiruvalluvar University, Tirupattur, Tamil Nadu, 635 601, India.
Bismuth ferrite (BiFeO) is a semiconductor with multiferroic properties, synthesized by the sol-gel method. While static high-pressure studies have advanced our understanding of the phase behavior of BiFeO, the effects of dynamic pressure acoustic shock waves remain unexplored. In this study, BiFeO was subjected to 100 shock pulses with 0.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
October 2025
Department of Sports Science, College of Natural Science, Jeonbuk National University, Jeonju, Republic of Korea.
Background: Fine particulate matter has developmental toxicity, and midgestation is an important period for the development of foetal skeletal muscle. The ability of exercise to modulate skeletal muscle damage in mice exposed to PM during gestation remains unclear.
Methods: Pregnant C57BL/6 mice were exposed to 50 μg/m PM for 2 h on five consecutive days starting at embryonic day 12.