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Background: Mood disorders and stress-related disorders are the two leading causes of long-term employee absenteeism and cause significant social losses. Therefore, strengthening the support systems is essential to help employees return to work.
Objective: This study aimed to investigate the outcomes of a return to work (RTW) rehabilitation program and to explore factors associated with RTW and continued employment.
Methods: A five-times-a-week RTW intervention was implemented for three to four months for people on leave who had been diagnosed with a mood or stress-related disorder. RTW rates within one year of completing the program and RTW retention rates one year after returning to work were examined to explore factors associated with RTW and employment retention.
Results: Of the 47 participants, 41 completed the RTW intervention, 35 returned to work (85.4%) within one year after the intervention, and 29 were still working one-year post their RTW (82.9%). The non-RTW group had a lower attendance rate for the program and showed an increase in anxious temperament. Additionally, compared to the RTW group, the non-RTW group showed significantly lower interpersonal relationship scores and decreased finger dexterity in the post-program evaluation, which may be associated with difficulties in returning to work. There was little improvement in cognitive function in the RTW non-continuation group, with a disrupted rhythm of life, depression, panic, and non-assertive self-expression.
Conclusion: The RTW intervention demonstrated effectiveness for treating patients with mood and stress-related disorders. Future studies should investigate comparative trials with a control group while also increasing the sample size.
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http://dx.doi.org/10.1177/10519815251335021 | DOI Listing |
Food Funct
September 2025
Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province 361021, PR China.
Depression is a widespread mental health condition associated with impaired neuroplasticity and disrupted brain-derived neurotrophic factor (BDNF)/TrkB signaling. Black mulberry, rich in anthocyanins, shows promise as a natural intervention for its anti-oxidative and anti-inflammatory profiles. This study evaluated the antidepressant-like effects of black mulberry anthocyanins in mice subjected to chronic mild stress (CMS).
View Article and Find Full Text PDFJ Affect Disord
September 2025
The Department of Decoded Neurofeedback, Computational Neuroscience Laboratories, Advanced Telecommunications Research Institute International (ATR), Kyoto, Japan; The Department of Psychiatry, Self-Defense Forces Hanshin Hospital, Kawanishi, Japan. Electronic address:
Background: Recent time-dependent analyses of stress-related disorders have identified heterogeneity of trajectories and their modifying factors. While psychiatric patients are vulnerable to stress events, it is unclear how psychiatric conditions in the general population modulate subsequent event-related distress trajectories.
Methods: Using a longitudinal online survey from before the COVID-19 pandemic to post-pandemic follow-ups (n = 3815 Japanese adults) and a latent growth mixture model, we identified four trajectories of pandemic-related stress symptoms: resilient, chronic, mild chronic, and early response.
ACS Chem Biol
September 2025
School of Applied Sciences and Engineering, CIBIOP Research Group, Universidad EAFIT, Carrera 45 No 7 Sur 50, Medellín, Colombia.
High salt concentrations affect the electron transport chain of bacterial cells, leading to an oxidative stress response that encompasses the formation of reactive oxygen species (ROS). The salt 2,3,5-triphenyltetrazolium chloride (TTC) triggers antibacterial activity against the phytopathogen in species; however, the underlying mechanisms remain unknown. Here, we tested the hypothesis that TTC-inducible activity is related to the formation of ROS and its metabolites.
View Article and Find Full Text PDFFront Neurosci
August 2025
The School of Life Sciences, Anhui University, Hefei, Anhui, China.
Increasing evidence suggests that all-trans retinoic acid (ATRA) contributes to the pathogenesis of depression. Although numerous studies have emphasized the role of hippocampal glutamatergic transmission and dendritic spine abnormalities in ATRA-induced depression, it remains unclear whether changes in hypothalamic glutamatergic transmission and dendritic spine density also contribute to its development. This study investigates the effects of ATRA treatment on glutamate receptor expression and dendritic spine density in the hypothalamus of rats.
View Article and Find Full Text PDFFront Hum Neurosci
August 2025
Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, United States.
Background: Cranial electrotherapy stimulation (CES) is a low-intensity, pulsed neuromodulation technique widely marketed for reducing stress and anxiety. Despite its popularity, empirical evidence for its efficacy remains mixed, with few studies employing rigorous controls, standardized protocols, and repeated CES exposures.
Objective: To evaluate whether repeated CES sessions can attenuate physiological, biochemical, cognitive, and affective responses to an acute laboratory stressor.