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Article Abstract
Biosensing technologies are facing increasingly urgent demands for highly sensitive and selective sensors. MXene, as a novel two-dimensional (2D) material, has emerged as an ideal candidate for sensors due to its ultrahigh conductivity and tunable surface functional groups. However, unmodified MXene lacks catalytic activity and specificity, limiting its applications. Surface-engineered X@MXene composites (X = metal oxides, aptamers, etc.) can significantly enhance catalytic activity and selectivity. This review systematically summarizes MXene synthesis strategies (HF etching, HF-free etching, vapor deposition, surface terminal group modulation), elucidates the regulatory mechanism of heterocomponents (X) on MXene catalytic pathways, analyzes its design principles in single-mode devices with different signal types (optical, electrical, colorimetric), and reveals the synergistic advantages of dual-mode sensors in sensitivity and anti-interference performance. This review provides theoretical guidance for designing high-performance MXene-based sensors, advancing their applications in precision medicine and intelligent monitoring.
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| http://dx.doi.org/10.1016/j.talanta.2025.128293 | DOI Listing |
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