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This study aimed to investigate the associations among life satisfaction, depressive symptoms, and common comorbid disorders during the COVID-19 pandemic. This combined cross-sectional and longitudinal study pooled national-level data from the 2021 Health and Retirement Study Perspectives on the Pandemic in the United States and the Big Data Drove Mental Health study in China. A total of 2,036 participants were included in this cross-sectional study conducted from July 2020 to August 2022. In this longitudinal prospective study, 4,503 participants were eligible for participation from January 2018 to June 2022. Life satisfaction was measured using five items from the Satisfaction with Life Scale. In a cross-sectional study, life satisfaction was found to be negatively associated with depressive symptoms, and depressive symptoms were comorbid with loneliness, anxiety, and dependency. The causal association between life satisfaction, depressive symptoms, and depressive symptoms comorbid with disorders was confirmed in a longitudinal prospective study. Low levels of life satisfaction increased the prevalence of comorbid disorders by 42.9% during the COVID-19 pandemic. Life satisfaction has played an important role during the COVID-19 pandemic and can be an effective strategy for depressive symptoms and depressive symptoms comorbid with disorder interventions among older adults.
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http://dx.doi.org/10.1111/aphw.70035 | DOI Listing |
Genes Brain Behav
October 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Major depressive disorder is a prevalent and debilitating psychiatric illness that produces significant disability. Clinical data suggest that the pathophysiology of depression is due, in part, to a dysregulation of inflammation and glutamate levels in the brain. The systemic administration of lipopolysaccharide (LPS) has been shown to induce depressive-like behaviors in mice.
View Article and Find Full Text PDFDev Psychopathol
September 2025
Department of Psychological Sciences, Kent State University, Kent, OH, USA.
Anxiety and depression symptoms and disorders are the leading child mental health problems in western societies. This systematic review evaluated how parental emotion socialization (ES) relates to children's internalizing problems (from birth to age 18 years). Three meta-analyses, evaluating supportive ( = 50, = 10,698), nonsupportive ES behaviors ( = 47, = 10,970), and elaboration ( = 6, = 867) were conducted.
View Article and Find Full Text PDFJ Neuropsychiatry Clin Neurosci
September 2025
Departments of Radiology, Neurology, and Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
Objective: One of the most frequent neuropsychiatric complications after a stroke is poststroke depression (PSD). However, it is unclear whether disparities exist in PSD diagnosis. The authors examined a 10-year trend in PSD by socioeconomic and clinical characteristics.
View Article and Find Full Text PDFJ Neuropsychiatry Clin Neurosci
September 2025
Department of Psychiatry and Behavioural Neurosciences, McMaster University and Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON.
Objective: The authors examined differences in resting-state functional connectivity (rsFC) in the brain between nontreatment-seeking adults with alcohol use disorder (case group) and recreational drinkers without alcohol use disorder (control group) and explored behavioral and psychological mechanisms underlying these differences.
Methods: This case-control study included 140 adults (N=71 with alcohol use disorder and N=69 demographically matched control individuals) who completed a 9-minute resting-state functional MRI scan. About 45% were men, and the mean±SD age was 32.
Ann Palliat Med
September 2025
Brown University Health Cancer Institute, Providence, RI, USA; Division of Geriatrics and Palliative Medicine, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, US.
ancreatic cancer is an aggressive disease and often presents at an advanced stage with no curative options. The disease is often characterized by rapid progression, limited or short-lived responsiveness to standard therapies, and a profound impact on patients' quality of life. Despite advances in targeted therapies and immunotherapy, curative outcomes remain elusive for the majority of patients with advanced or high-grade disease with a 5-year survival rate of less than 10%.
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