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http://dx.doi.org/10.2215/CJN.0000000710 | DOI Listing |
Cell Mol Biol (Noisy-le-grand)
September 2025
Medical School, Laboratory of Genetics and Molecular Pathology, University Hassan II, Casablanca, Morocco.
In-stent restenosis remains a significant challenge in interventional cardiology despite technological advancements. This retrospective case-control study conducted at the University Hospital Center Ibn Rochd in Casablanca (2020-2023) examined risk factors associated with coronary in-stent restenosis in 68 patients equally distributed between restenosis and no-restenosis groups. Diabetes emerged as a powerful predictor of restenosis (RR=4.
View Article and Find Full Text PDFJ Med Chem
September 2025
Applied Pharmaceutical Science, Inc., Building 10-1, No.2, Jingyuan North Street, BDA, Beijing 100176, China.
This study reports the discovery and preclinical activity of APS03118, a novel selective RET inhibitor featuring a novel tricyclic pyrazolo[3',4':3,4]pyrazolo[1,5-]pyridine hinge-binding scaffold designed to overcome acquired resistance to first-generation selective RET inhibitors (SRIs). By enhancing hydrogen bonding with conserved hinge residues (Glu805, Ala807), APS03118 potently inhibits wild-type RET and diverse resistance mutations, including solvent-front (G810R/S/C), gatekeeper (V804M/L/E), roof (L730I/M), and hinge (Y806C/N/H) variants. In preclinical models, APS03118 induced complete tumor regression in KIF5B-RET and CCDC6-RET V804 M patient-derived xenografts (PDXs) and significantly prolonged survival in an intracranial CCDC6-RET metastasis model.
View Article and Find Full Text PDFJ Med Chem
September 2025
Repare Therapeutics, 7171 Frederick-Banting, Building 2, H4S 1Z9 Montréal, Québec, Canada.
DNA polymerase theta (Polθ) plays a critical role in repairing DNA double-strand breaks through microhomology-mediated end joining (MMEJ) and has emerged as a key synthetic lethal drug target in cancers with homologous recombination (HR) deficiencies. Its inhibition has shown a strong potential to synergize with PARP inhibitors, particularly in tumors with deleterious or mutations. Here, we describe the discovery and preclinical development of RP-2119, a selective, potent, and bioavailable Polθ ATPase inhibitor.
View Article and Find Full Text PDFSci Prog
September 2025
School of International Finance and Trade, Shanghai International Studies University, Shanghai, China.
To explore the alleviating effect of digital supply chain finance (DSCF) on financing constraints experienced by small- and medium-sized enterprises (SMEs), with a view to promoting the digital transformation of enterprises. This observational study utilizes data from Chinese listed enterprises. The study's primary focus is on a selection of SRDI (abbreviation for "specialized, refined, distinctive, and innovative") enterprises in the electronics and machinery industries from 2013 to 2020.
View Article and Find Full Text PDFChaos
September 2025
Complex Systems Group & Grupo Interdisciplinar de Sistemas Complejos, Universidad Rey Juan Carlos, 28933 Móstoles, Madrid, Spain.
A flat control law is based on the structural analysis of a controlled system, allowing optimal placement of sensors and actuators. Once designed, any desired dynamics can be imposed onto the system. When the target dynamics comes from a system structurally different from the controlled one, generalized synchronization can be achieved, provided the control gain is sufficiently large.
View Article and Find Full Text PDF