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This paper presents a novel multi-scale, noise-robust edge detection method that employs multi-scale automatic anisotropic morphological Gaussian kernels to extract edge maps from input images. It addresses the issue of cross-edge detection failure in the Canny edge detector. Compared to other edge detection methods, the proposed approach offers significant advantages in maintaining noise robustness while achieving high edge resolution and accuracy. The paper is structured into five key sections. First, we propose a multi-scale automatic anisotropic morphological directional derivative (AMDD) to capture local gray-level variations around each pixel at multiple scales. Second, a new fused edge strength map (ESM) is introduced based on the multi-scale AMDD. Third, we analyze why the Canny isotropic Gaussian kernel detector fails to detect cross edges. Additionally, the edge contour is extracted by incorporating the fused ESMs and the edge direction map (EDM), which are processed through spatial and directional matching filters, into the standard Canny detection framework. Finally, we evaluate the proposed method using precision-recall (PR) curves and Pratt's Figure of Merit (FOM). We compare its performance with existing state-of-the-art detectors on a standard dataset. Experimental results demonstrate that the proposed method effectively reduces noise, mitigates irrelevant signal interference, and smooths the image, showing competitive performance in edge detection tasks.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052157 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0319852 | PLOS |
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September 2025
Institute of Thin Film Physics and Applications, Shenzhen Key Laboratory of Advanced Thin Films and Applications, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, State Key Laboratory of Radio Frequency Heterogeneous Integration, College of Physic
Antimony selenide (SbSe), a narrow-bandgap semiconductor with strong light absorption, exhibits photoresponse up to ≈1050 nm due to its intrinsic 1.15 eV bandgap. To extend detection into the near-infrared (NIR, 700-1350 nm), Bi-alloyed (BiSb)Se is developed via vacuum sputtering and postselenization.
View Article and Find Full Text PDFJ Multidiscip Healthc
September 2025
Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Background: Falls are a major cause of injury and death among the elderly, highlighting the need for effective and real-time detection systems. Embedded Internet of Health Things (IoHT) technologies integrating sensors, microcontrollers, and communication modules offer continuous monitoring and rapid response. However, the research landscape remains fragmented, and no comprehensive bibliometric review has been conducted.
View Article and Find Full Text PDFNat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Division of Sleep Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States; Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University, Clevelan
Obstructive sleep apnea (OSA) is a pervasive disorder characterized by recurrent airway obstructions during sleep. OSA carries serious health risks, such as cardiovascular and cognitive impairments, and imposes a significant economic burden. This chapter provides a comprehensive overview of various biosensors currently employed for OSA detection, including in-lab polysomnography and flow-based home sleep apnea testing.
View Article and Find Full Text PDFCancer Res
September 2025
Morgridge Institute for Research, Madison, Wisconsin, United States.
Patient-derived cancer organoids (PDCOs) are a valuable model to recapitulate human disease in culture with important implications for drug development. However, current methods for rapidly and reproducibly assessing PDCOs are limited. Label-free imaging methods are a promising tool to measure organoid level heterogeneity and rapidly screen drug response in PDCOs.
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