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http://dx.doi.org/10.1053/j.gastro.2025.03.050 | DOI Listing |
Expert Opin Biol Ther
September 2025
Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Background: Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Although UST has demonstrated good efficacy and safety in CD, long-term real-world data in Chinese patients are relatively scarce.
Methods: A single-center, observational retrospective study was conducted in the First Affiliated Hospital of Anhui Medical University.
World J Clin Pediatr
September 2025
Department of Histopathology, Manipal Hospitals, Kolkata 700029, West Bengal, India.
Background: Eosinophilic gastrointestinal (GI) disease (EGID) beyond eosinophilic esophagitis is not commonly reported in the developing world.
Aim: To estimate the prevalence of EGID in a selected group of pediatric patients suffering from non-functional chronic abdominal pain (CAP).
Methods: A retrospective analysis was conducted on case records of children with CAP.
Children (Basel)
July 2025
Parasite & Health Research Group, Department of Pharmacy, Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, 46100 Valencia, Spain.
Undernutrition and intestinal parasitic infections are critical public health problems in low-income countries, with adverse effects on child growth and increasing anaemia. Madagascar, with a high prevalence of these factors, lacks comprehensive studies analysing their interaction. This study aimed to assess the nutritional status, the prevalence of anaemia, and the occurrence of intestinal parasitic infections among children and adolescents in three southern regions of Madagascar.
View Article and Find Full Text PDFBackground: Patients affected by glucose-6-phosphate dehydrogenase (G6PDH) deficiency are often asymptomatic until an oxidative stress occurs, causing acute hemolytic anemia. The coexistence of hemolytic crisis secondary to G6PDH deficiency and methemoglobinemia is an already known phenomenon, especially after the ingestion of fava beans. While past literature described this association primarily in adult patients, it remains an unusual finding in pediatric population.
View Article and Find Full Text PDFJ Med Screen
August 2025
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
ObjectivesTo assess variation in fecal hemoglobin concentration according to year and season of fecal immunochemical test screening in Sweden, the detection rate of advanced neoplasia, and factors that could influence fecal immunochemical test positivity including sex, age, comorbidity, and laboratory testing quality.MethodsWe performed a cross-sectional analysis of participants in the fecal immunochemical test arm of the randomized controlled trial SCREESCO between March 2014 and December 2019 and of participants in the screening program of Stockholm-Gotland, Sweden, who underwent a one-sample fecal immunochemical test between October 2015 and October 2024.ResultsA total of 33,232 individuals from SCREESCO and 315,664 individuals from the Stockholm-Gotland screening program were included.
View Article and Find Full Text PDF