Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient.

Background: Patients affected by glucose-6-phosphate dehydrogenase (G6PDH) deficiency are often asymptomatic until an oxidative stress occurs, causing acute hemolytic anemia. The coexistence of hemolytic crisis secondary to G6PDH deficiency and methemoglobinemia is an already known phenomenon, especially after the ingestion of fava beans. While past literature described this association primarily in adult patients, it remains an unusual finding in pediatric population.

Pediatric Langerhans Cell Histiocytosis: Unifocal Localization in the Frontal Bone Presenting With Periorbital Swelling.

Langerhans cell histiocytosis is a rare disease, the pathogenesis of which remains a subject of debate, with considerations of either a neoplastic origin or an inflammatory nature. It arises from the uncontrolled proliferation of immature myeloid dendritic cells, leading to their accumulation in various sites. Recent studies indicate that Langerhans cell histiocytosis is a clonal neoplastic disorder driven by mutations in the MAP kinase pathway.