Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We aimed to investigate the roles and interaction effects of high-risk human papillomavirus (HR-HPV) infection, methyltetrahydrofolate reductase polymorphism, and paired box gene 1 () methylation in cervical intraepithelial neoplasia (CIN) and cervical cancer. Polymerase chain reaction was used to detect polymorphism and methylation; Mantel-Haenszel and Spearman's rank correlation tests were used to analyze the trends and correlations. Forty cases each of normal control (NC), CIN I, and CIN II/III and 9 squamous cell carcinoma (SCC) cases were enrolled. Increase in age increases the risk of cervical cancer. The HR-HPV infection rate, mutation rate, and methylation rate in CIN I, CIN II/III, and SCC groups were significantly higher than those in the NC group ( < 0.05). The above-mentioned rates gradually increased with the degree of cervical lesions. Moreover, HR-HPV infection, polymorphism, and methylation increased the risk of both CIN and cancer. A positive additive interaction was observed between methylation and polymorphism across different cervical lesion groups, whereas no interaction was found between HR-HPV infection and methylation in lesion progression.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032982 | PMC |
| http://dx.doi.org/10.1515/biol-2022-1052 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Retrospective analysis of the impact of human papillomavirus infection in the male genital tract on sperm: from a single center.
Front Cell Infect Microbiol
September 2025
Department of Pathology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
Objective: This study primarily aimed to investigate human papillomavirus (HPV) infection in males and to evaluate its effect on semen parameters, fertility and partner HPV infection status.
Methods: A total of 624 men who visited the West China Second Hospital of Sichuan University between October 1, 2019, and September 30, 2023, were included. HPV DNA was detected in exfoliated cells from the male genitalia using polymerase chain reaction (PCR) and reverse membrane hybridization to analyze the relationship between HPV infection and semen parameters.
Harnessing the Power of Microbiota: How Do Key Species Aid in Clearing High-Risk Human Papilloma Virus Infection and Promoting the Regression of Cervical Dysplasia?
Biology (Basel)
August 2025
Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
species play a fundamental role in maintaining a healthy vaginal microbiota and have been increasingly recognized for their protective effects against high-risk human papillomavirus (HR-HPV) infection and the progression of cervical intraepithelial neoplasia (CIN). These beneficial bacteria contribute to host defense through multiple mechanisms, including the production of lactic acid that sustains a low vaginal pH, enhancement of epithelial barrier integrity via E-cadherin regulation, and modulation of immune signaling pathways such as interferon responses and NF-κB activity. strains exert anti-inflammatory effects by downregulating pro-inflammatory cytokines and interfering with oncogenic pathways including Wnt/β-catenin and the expression of HPV E6 and E7 proteins.
View Article and Find Full Text PDFAssociation between cervical intraepithelial neoplasia progression and cervicovaginal microbiota status - narrative review.
Folia Med Cracov
December 2024
University Hospital in Kraków, Clinical Department of Gynecological Oncology and Gynecology; Jagiellonian University Medical College, Faculty of Medicine, Department of Gynecology and Obstetrics, Kraków, Poland.
In 2022, an estimated 660 000 women were diagnosed with cervical cancer worldwide and about 350 000 women died from the disease. Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical precancer and cancer.
View Article and Find Full Text PDFHigh-risk HPV infection and the risk of preterm birth in a Romanian tertiary maternity cohort: a prospective observational study.
J Med Life
July 2025
Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Preterm birth (PTB; < 37 weeks) affects 10 % of pregnancies and is the leading cause of neonatal mortality. Whether maternal high-risk human papillomavirus (hr-HPV) infection contributes to spontaneous PTB is unsettled. Romania, with Europe's highest cervical-cancer burden, offers a relevant setting to explore this association.
View Article and Find Full Text PDFCervical Cytology-Based Screening Identifies Trichomonas vaginalis as a Significant Correlate of Non-16/18 High-Risk Human Papillomavirus Infection in High-Altitude Tibetan Agro-Pastoral Communities: A Cross-Sectional Study of 62,657 Women.
Int J Infect Dis
August 2025
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.. Electronic address:
Background: The epidemiological relationship between Trichomonas vaginalis (TV) and high-risk human papillomavirus (HR-HPV) remains controversial in high-altitude populations.
Methods: This was a cross-sectional analysis of 62,657 asymptomatic women from China's Cervical and Breast Cancer Screening Program in Tibetan agro-pastoral communities (2019-2024). TV was microscopically identified through microbial evaluation via Pap smear in cervical cytology; HR-HPV genotypes were detected using commercial kit.