Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Days of Antibiotic Spectrum Coverage (DASC) is a novel metric assessing antibiotic use in stewardship. This study evaluated its validity by comparing ASC scores with Japanese pharmacists' evaluations. Discrepancies in ASC scores for some antimicrobial agents indicate that local adjustments are needed to enhance clinical relevance and acceptability.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2025.116839DOI Listing

Publication Analysis

Top Keywords

days antibiotic
8
antibiotic spectrum
8
spectrum coverage
8
coverage dasc
8
asc scores
8
gaps days
4
dasc clinical
4
clinical sense
4
sense antimicrobial
4
antimicrobial spectrum
4

Similar Publications

Background: Intravenous lipid emulsions are a key component of parenteral nutrition, and their fatty acid compositions may influence immune responses and clinical outcomes.

Methods: This retrospective cohort study conducted from January 2020 to December 2022 compared clinical outcomes of hospitalized non-critical care patients receiving parenteral nutrition with either mixed oil or soybean oil lipid emulsions for at least 48 h. The primary outcome was a composite of the presence of pneumonia, urinary tract infection, or an intra-abdominal collection diagnosed within 14 days of initiating parenteral nutrition.

View Article and Find Full Text PDF

Exploration of zileuton protective mechanisms against vancomycin-associated nephrotoxicity.

Toxicol Appl Pharmacol

September 2025

Department of Pharmacological & Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204, United States; Department of Pharmacy Practice & Translational Research, University of Houston College of Pharmacy, Houston, TX 77204, United States. Electronic address:

Vancomycin is one of the most commonly used parenteral antibiotics for treating drug-resistant bacterial infections, however, it is hindered by nephrotoxicity. We previously demonstrated that zileuton could delay the onset of vancomycin-associated nephrotoxicity in rats. Here, we sought to understand the mechanism(s) of zileuton renal protection.

View Article and Find Full Text PDF

Co-existence of mcr-1 and bla from porcine-derived Escherichia coli isolated in China and selection of mcr-1 under cephalosporins pressure.

J Glob Antimicrob Resist

September 2025

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, Jilin 130122, China. Electronic address:

Objectives: The usage of cephalosporins (CEFs) and co-existence of extended-spectrum β-lactamase (ESBL) gene bla in the same host may promote the prevalence of colistin (CST) resistance gene mcr-1. This study aims to investigate the underlying mechanisms how the mcr-1 and bla demonstrate significant co-occurrence in Escherichia coli (E. coli).

View Article and Find Full Text PDF

Management on late diagnosed Fournier's gangrene in elderly patient and it's complication: A case reports.

Int J Surg Case Rep

September 2025

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Biomedical Science, Faculty of Medicine, Universitas Surabaya, Indonesia.

Introduction And Importance: One of the risk factors linked to mortality in Fournier Gangrene (FG) is the elderly. When this risk is present and diagnosed too late, patient care may become difficult. This case report discusses the treatment of an older patient with late-diagnosed Fournier's gangrene and its consequences in this background.

View Article and Find Full Text PDF

Synergistic enhancement effect of straw-earthworms in the reduction of sulfamethoxazole and antibiotic resistance genes.

Ecotoxicol Environ Saf

September 2025

Institute of Eco-Environment and Plant Protection, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai 201403, China. Electronic address:

Soil antibiotic pollution is a global concern. It has been confirmed that straw or earthworm can enhance microbial degradation of antibiotics in soil. However, in the C/N transformation processes of soil ecosystems, straw and earthworms are closely interconnected.

View Article and Find Full Text PDF