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Days of Antibiotic Spectrum Coverage (DASC) is a novel metric assessing antibiotic use in stewardship. This study evaluated its validity by comparing ASC scores with Japanese pharmacists' evaluations. Discrepancies in ASC scores for some antimicrobial agents indicate that local adjustments are needed to enhance clinical relevance and acceptability.
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http://dx.doi.org/10.1016/j.diagmicrobio.2025.116839 | DOI Listing |
JPEN J Parenter Enteral Nutr
September 2025
Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada.
Background: Intravenous lipid emulsions are a key component of parenteral nutrition, and their fatty acid compositions may influence immune responses and clinical outcomes.
Methods: This retrospective cohort study conducted from January 2020 to December 2022 compared clinical outcomes of hospitalized non-critical care patients receiving parenteral nutrition with either mixed oil or soybean oil lipid emulsions for at least 48 h. The primary outcome was a composite of the presence of pneumonia, urinary tract infection, or an intra-abdominal collection diagnosed within 14 days of initiating parenteral nutrition.
Toxicol Appl Pharmacol
September 2025
Department of Pharmacological & Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204, United States; Department of Pharmacy Practice & Translational Research, University of Houston College of Pharmacy, Houston, TX 77204, United States. Electronic address:
Vancomycin is one of the most commonly used parenteral antibiotics for treating drug-resistant bacterial infections, however, it is hindered by nephrotoxicity. We previously demonstrated that zileuton could delay the onset of vancomycin-associated nephrotoxicity in rats. Here, we sought to understand the mechanism(s) of zileuton renal protection.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
September 2025
Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, Jilin 130122, China. Electronic address:
Objectives: The usage of cephalosporins (CEFs) and co-existence of extended-spectrum β-lactamase (ESBL) gene bla in the same host may promote the prevalence of colistin (CST) resistance gene mcr-1. This study aims to investigate the underlying mechanisms how the mcr-1 and bla demonstrate significant co-occurrence in Escherichia coli (E. coli).
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Biomedical Science, Faculty of Medicine, Universitas Surabaya, Indonesia.
Introduction And Importance: One of the risk factors linked to mortality in Fournier Gangrene (FG) is the elderly. When this risk is present and diagnosed too late, patient care may become difficult. This case report discusses the treatment of an older patient with late-diagnosed Fournier's gangrene and its consequences in this background.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Institute of Eco-Environment and Plant Protection, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China; Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai 201403, China. Electronic address:
Soil antibiotic pollution is a global concern. It has been confirmed that straw or earthworm can enhance microbial degradation of antibiotics in soil. However, in the C/N transformation processes of soil ecosystems, straw and earthworms are closely interconnected.
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