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The safety of underlying metro tunnels is significantly compromised when the excavation of the overlying foundation pit is not properly conducted. Currently, research on the longitudinal deformation of tunnels induced by upper excavation typically relies on the Pasternak model, which assumes the tunnel behaves as a slender beam with a circular cross-section. However, due to the complexity in characterizing convergence deformation under lateral loading conditions, few studies have systematically explored its influence on the tunnel deformation. In this study, a theoretical model considering the lateral response of the tunnel was developed. Then, analytical evaluations of engineering cases were performed to validate the model's accuracy. The results indicate that the proposed model provides a more accurate prediction of tunnel deformation due to overlying excavation compared to the Pasternak and Winkler foundation model. Additionally, the maximum vertical displacement of the tunnel increased with the widening of the foundation pit. It was also found that the maximum vertical displacement of the tunnel decreased almost linearly with an increase in the burial depth of the tunnel. In comparison to these two factors, the distance between the tunnel axis and the foundation pit had less influence on the tunnel deformation induced by excavation. The conclusions provide a theoretical reference for engineering calculations and practical applications.
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http://dx.doi.org/10.1038/s41598-025-99746-7 | DOI Listing |
Invest Ophthalmol Vis Sci
September 2025
The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, Leicester, United Kingdom.
Purpose: To define the genetic architecture of foveal morphology and explore its relevance to foveal hypoplasia (FH), a hallmark of developmental macular disorders.
Methods: We applied deep-learning algorithms to quantify foveal pit depth from central optical coherence tomography (OCT) B-scans in 61,269 UK Biobank participants. A genome-wide association study (GWAS) was conducted using REGENIE, adjusting for age, sex, height, and ancestry.
Nat Commun
August 2025
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Fusobacterium nucleatum is overrepresented in the colon microbiome of colorectal cancer patients and has been associated with tumor growth enhancement and metastasis. A pivotal pathogenic factor, the autotransporter adhesin Fap2, facilitates association to cancer and immune cells via the receptors Gal-GalNAc and TIGIT, respectively, leading to deactivation of immune cells. Mechanistic details of the Fap2/TIGIT interaction remain elusive as no structural data are available.
View Article and Find Full Text PDFMolecules
August 2025
Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900, China.
Low-temperature plasma cleaning technology has been widely used to clean various optical components precisely. After the complete removal of organic contaminants from fused silica surfaces through plasma cleaning, continuous plasma irradiation can lead to nano-defects on the fused silica surface, resulting in the degradation of optical performance. Thus, the microscale processes underlying plasma-induced surface damage on fused silica were investigated through molecular dynamics simulations, aiming to analyze the mechanisms of surface damage on optical components during plasma cleaning.
View Article and Find Full Text PDFMaterials (Basel)
August 2025
College of Science, Inner Mongolia University of Technology, Huhhot 010051, China.
The present study aims to investigate the orientation-dependent mechanical behaviors of ZnO single crystals under nanoindentation by molecular dynamics simulation. The load-indentation depth curves, atomic displacement, shear strain and dislocations for the c-plane, m-plane and a-plane ZnO single crystals were analyzed in detail. The simulation results showed that the elastic deformation stage of the loading curves for the three oriented ZnO single crystals can be described well by the Herz elastic contact model.
View Article and Find Full Text PDFHum Brain Mapp
September 2025
Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, New York, USA.
Understanding the development of complex brain surface morphologies during the fetal stage is essential for uncovering mechanisms underlying brain disorders linked to abnormal cortical folding. However, knowledge of the spatiotemporal evolution of fetal brain landmarks remains limited due to the lack of longitudinal data capturing multiple timepoints for individual brains. In this study, we develop and validate an image-based true-scale mechanical model to investigate the spatiotemporal evolution of brain sulcal pits in individual fetal brains.
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