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http://dx.doi.org/10.1016/j.lssr.2025.03.005 | DOI Listing |
Sci Adv
September 2025
School of Engineering and Materials Science, Queen Mary University of London, UK.
During heart disease, the cardiac extracellular matrix (ECM) undergoes a structural and mechanical transformation. Cardiomyocytes sense the mechanical properties of their environment, leading to phenotypic remodeling. A critical component of the ECM mechanosensing machinery, including the protein talin, is organized at the cardiomyocyte costamere.
View Article and Find Full Text PDFRev Sci Instrum
September 2025
Leiden Institute of Physics, Leiden University, 2333CC Leiden, The Netherlands.
Whether at the molecular or cellular scale in organisms, cell-cell adhesion adapts to external mechanical cues arising from the static environment of cells and from dynamic interactions between neighboring cells. Cell-cell adhesion needs to resist detachment forces to secure the integrity and internal organization of organisms. In the past, various techniques have been developed to characterize adhesion properties of molecules and cells in vitro and to understand how cells sense and probe their environment.
View Article and Find Full Text PDFTransl Vis Sci Technol
September 2025
The Centers for Advanced Surgical Exploration (CASEx), Miami, FL, USA.
Purpose: Suprachoroidal (SC) drug delivery is a promising avenue for treating posterior segment ocular diseases. Current ex vivo models, primarily human cadaveric eyes, are limited by tissue variability and altered post-mortem fluid dynamics. We introduce near-real surgical specimens (NRSS), an engineered ocular tissue platform, to overcome these limitations and provide standardized, reproducible evaluation of SC drug delivery.
View Article and Find Full Text PDFJ Exp Bot
September 2025
Centre for Plant Sciences, Bragg Centre for Materials Research and The Astbury Centre, School of Biology, University of Leeds, Leeds, LS2 9JT, UK.
Plant cell walls exist as a complex and varied blend of polysaccharides and proteins; the combination of which has evolved over millions of years. Research on how these components interact is key to understanding a plant's mechanical, structural, communicative, and biological traits. However, knowledge on cell wall components, its biophysical properties and cellular functions remains sparse.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
July 2025
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, China Academy of Chinese Medical Sciences Beijing 100700, China.
Traditionally, Dao-di herbs refer to high-quality traditional Chinese medicine(TCM) produced in specific geographical regions. The development of their assessment theory holds profound significance for ensuring the stability of clinical efficacy and advancing the heritage and modernization of TCM. The concept of assessing Dao-di herbs originated in the Eastern Han Dynasty.
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