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In this work, AlGaN/GaN high-electron-mobility transistors (HEMTs) with a nanocrystalline diamond (NCD)/SiN trench dual-passivated (TDP) structure were promoted, which demonstrated superior performance with a higher saturation output current () of 1.266 A/mm, a higher maximum transconductance () of 0.329 S/mm, and a lower resistance () of 2.64 Ω·mm. Thermal simulations revealed a peak junction temperature of 386.36 K for TDP devices under / = 30 V/0 V, representing 13.7% and 4.5% reductions versus SiN single-passivated (SP, 447.59 K) and dual-passivated (DP, 404.58 K) devices, respectively. The results suggested that compared to conventional SP and DP devices, TDP devices can effectively suppress the self-heating effect, thereby improving output characteristics while maintaining superior RF small-signal characteristics. Moreover, the results of numerical simulations indicated that the enhanced electrothermal performance of TDP devices was predominantly attributed to the mitigation of temperature-induced degradation in electron mobility and drift velocity, thereby preserving their high power and high frequency capabilities. These results highlighted the significant potential of TDP devices to improve the performance of GaN HEMTs in high-power and high-frequency applications.
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http://dx.doi.org/10.3390/nano15080574 | DOI Listing |
Nat Commun
September 2025
Medical Research Center, Seoul National University, Seoul, Republic of Korea.
Recent advancements in implantable bioelectronic devices have increased the demand for biocompatible energy sources with long-term electrochemical and mechanical stability. Here, we present a tough hydrogel-based supercapacitor (THBS) fiber, fabricated via a thermal drawing process (TDP), that enables the integration of all components-electrodes, electrolyte, current collectors, and encapsulation-into a single, unified, and mechanically robust fiber-shaped architecture. Through thermal/mechanical optimization and the incorporation of self-healing properties, THBS fibers exhibit durable, high electrochemical performance under dynamic, high-curvature deformations mimicking in vivo physiological motions.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
August 2025
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Bottom-up proteomics introduces proteoform ambiguity due to the loss of connectivity between peptides and their original proteoforms. Top-down proteomics (TDP) removes the ambiguity through the direct identification and characterization of intact proteoforms and their respective post-translational modifications (PTM). Electron capture dissociation (ECD) is an efficient and gentle peptide and protein fragmentation strategy that can be used for both bottom-up and top-down approaches.
View Article and Find Full Text PDFZhonghua Xin Xue Guan Bing Za Zhi
August 2025
Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine Tsinghua Medicine, Tsinghua University, Beijing 102218, China.
To analyze the electrocardiogram (ECG) data of congenital long QT syndrome (LQTS) patients, and to identify the ECG parameters for prediction of life-threatening arrhythmic events (LAEs). This cohort study enrolled patients diagnosed with congenital LQTS at the Department of Cardiology, Beijing Tsinghua Changgung Hospital from September 2014 to May 2023. Baseline clinical and ECG data were collected.
View Article and Find Full Text PDFEnviron Res
August 2025
Instituto de Ciencias de La Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico.
Cardiac damage and neurodegeneration simultaneously evolve in children and young adults, exposed to environmental oxidative, magnetic, motion capable, ultrafine particulate matter (UFPM) and industrial nanoparticles (NPs). Particles move in situ when exposed to DC/AC magnetic 30-50 μT fields, and are documented in fetal hearts, brains and placentas. We identify magnetic NPs and measured motion behavior under AC and DC fields in ventricles, septum, atrioventricular (AV) conduction axis, auricles and ventricles, in healthy hearts of 18 Metropolitan Mexico City (MMC) 30.
View Article and Find Full Text PDFToxicol Lett
August 2025
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Neonicotinoids are high affinity agonists of insect Nicotinic Acetyl Choline Receptors (nAChRs) resulting in insect paralysis and death. Although they are assumed to have relatively low affinity towards mammalian and other non-insect nAChRs, studies have shown that they can cause neuro-endocrine toxicity, immunotoxicity and endocrine toxicity. Moreover, as a result of bioaccumulation the levels of neonicotinoids can be even traced in non-farming population at an significant level.
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