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Polysaccharide-based hydrogels possess desirable characteristics such as flexibility, biocompatibility, and biodegradability. Nevertheless, these hydrogels frequently lose their inherent traits and functionality under low-temperature circumstances, which significantly restricts their potential applications in cold environments. Antifreeze hydrogels provide a promising solution to this challenge by maintaining their properties at cold temperatures, showcasing remarkable advantages. This review commences with a bibliometric analysis via VOS Viewer to acquire a comprehensive comprehension of the development tendencies in antifreeze hydrogels. It subsequently summarizes diverse antifreeze mechanisms in polysaccharide-based hydrogels, encompassing solute ion modification, organic alcohol modification, ion gels, eutectic gels, and intrinsic antifreeze properties through molecular chain polymerization. Additionally, the review explores the applications of antifreeze hydrogels in food preservation, flexible wearable devices, and energy storage. Finally, the future directions for the development of antifreeze polysaccharide-based hydrogels are deliberated, with an emphasis on the utilization of natural polysaccharide resources to create hydrogels that integrate antifreeze performance, mechanical properties, and stability, thereby facilitating advancements in related industries.
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http://dx.doi.org/10.1016/j.ijbiomac.2025.143317 | DOI Listing |
Carbohydr Polym
November 2025
Department of Polymers for Health and Biomaterials, IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France; Department of Pharmacy, Nîmes University Hospital, 30900 Nimes, France. Electronic address:
Polysaccharide-based hydrogels often lack mechanical strength and, when used for protein delivery, are generally limited to diffusion-based release. In this work, we developed robust polysaccharide- and polyester-based near-infrared (NIR)-responsive hydrogels. Hydrogels are made from photo-crosslinked methacrylated dextran (DEX-MA), methacrylated polylactide containing oxygen reactive species (ROS) sensitive thioketal groups (PLA-TK-MA), and covalently bound protoporphyrin IX (PPIX) that generates ROS under NIR irradiation.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
National Center for Orthopaedics, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Intervertebral disc degeneration (IVDD) is a primary contributor to chronic low back pain (LBP) and neurological dysfunction. It significantly impairs patients' quality of life. With an aging population and changing lifestyles, the incidence of IVDD has been rising steadily.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Graduate School, School of Kinesiology and Health, Harbin Sport University, Harbin 150008, PR China.
Owing to the rapid advancement of wearable electronics and soft robotics, anti-swelling hydrogels have attracted considerable interest for underwater motion sensing because of their outstanding stability under aqueous conditions. Herein, this review first catalogues polysaccharide-based building blocks employed to engineer anti-swelling hydrogels, then systematically discuss structural design strategies and review recent advances in their application to motion sensing. This review first summarizes the use of natural polysaccharides-including chitosan and sodium alginate-for preparing anti-swelling hydrogels.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi 712100, China.
Antibacterial polysaccharides are emerging as viable substitutes for conventional antibiotics by combining a variety of bactericidal mechanisms with their inherent biocompatibility and biodegradability. This study reviewed findings from articles (approximately 110 manuscripts published between 2013 and 2024), reporting sources, extraction and use of polysaccharides (with antibacterial properties) from nature such as microbiological exopolysaccharides, chitosan and alginate. A lot of natural polysaccharides, like chitosan and alginate, possess the ability to break down bacterial cell walls and biofilms, but they don't harm human cells or even commensal microbiota.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Hebei Chemical & Pharmaceutical College, Shijiazhuang 050026, China. Electronic address:
Bacterial infections and excessive inflammation represent significant challenges in diabetic wound healing, severely impairing tissue repair. To address these issues, functional dressings with antibacterial and anti-inflammatory properties show great value. Based on this, we developed a new multifunctional hydrogel dressing composed of Gastrodia elata polysaccharide (GEP)/gelatin methacrylated (GM) loaded with glycyrrhizic acid/iron (GF) nanoparticles to enhance Staphylococcus aureus (S.
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