Cumulative exposure assessment to polychlorinated alkanes (C) to indoor dust from Iranian kindergartens: Occurrence and health risk.

The environmental and public health concerns associated with chlorinated paraffins (CPs) are significant, given their widespread use, long-lasting persistence, and potential adverse health effects. The objective of this study was to assess the contamination of polychlorinated alkanes (PCAs-C), the major contaminants in the CP technical mixtures, in kindergartens in Tehran, Iran, and to evaluate the cumulative exposure risks through various routes, including ingestion, dermal contact, and inhalation of dust. The results revealed a pervasive contamination with PCAs. The sum of PCAs-C across all samples was found to be 1370 ng/g dw, with median values of 500 ng/g dw for ∑PCAs-C, 620 ng/g dw for ∑PCAs-C, and 280 ng/g dw for ∑PCAs-C. These levels did not correlate with outdoor environmental factors or indoor characteristics. Dermal contact constituted 64-84 % of total exposure, with toddlers showing higher intake than caretakers. A cumulative exposure assessment was conducted to calculate the hazard quotient (HQ). The highest HQ value was observed for girls in the case of ∑PCAs-C (6.2 × 10), and the HQ for all groups remained well below the risk threshold. Despite the low level of immediate risks, chronic exposure in vulnerable population groups justifies proactive measures. Further investigation of exposure sources and implementation of interventions to reduce potential health risks are recommended, given the ubiquity of CPs in indoor environments. ENVIRONMENTAL IMPLICATIONS: This study highlights significant environmental implications of pervasive polychlorinated alkanes (PCAs-C) contamination in Tehran's kindergartens, highlighting their persistence and potential long-term ecological impacts. Despite cumulative exposure risks (HQs <1) via dust ingestion, dermal contact, and inhalation, the ubiquity of PCAs (∑PCAs-C: 1370 ng/g dw) raises concerns about chronic low-dose exposure in vulnerable toddlers. The lack of correlation between contamination levels and environmental/indoor factors suggests complex, unidentified emission sources. These findings emphasize the need for proactive regulatory measures to mitigate CP releases and prioritize indoor environmental quality, particularly in child-centric settings. Further research is critical to identify exposure pathways and inform policies safeguarding public health against persistent organic pollutants.