98%
921
2 minutes
20
Background: Odontogenic brain abscess is a rare, but potentially fatal, central nervous system infection, with insidious onset and unclear etiology.
Methods: This case reports a 70-year-old male patient who developed an odontogenic brain abscess secondary to periodontal infection and underwent neurological surgery. Extract pus during surgery for the metagenomic next-generation sequencing (mNGS).
Results: The mNGS of pus samples obtained from brain abscess aspiration identified the periodontal pathogens and . Consequently, he was referred to the department of stomatology for further examination and treatment.
Conclusions: Our study found that major periodontal pathogens including and were essential in the development of odontogenic brain abscesses; thus, timely intervention and preventive measures are important for treatment.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001842 | PMC |
http://dx.doi.org/10.1080/20002297.2025.2485197 | DOI Listing |
Cureus
July 2025
Department of Prosthodontics, Medical University of Lodz, Lodz, POL.
A brain abscess (BA) is a purulent infection of the central nervous system and can be associated with dental procedures. The paper presents a case of a patient diagnosed with an odontogenic BA. On admission, the patient was awake, alert, and oriented (Glasgow Coma Scale 15).
View Article and Find Full Text PDFElife
July 2025
Department of Oral Biology, College of Dentistry, University of Illinois Chicago, Chicago, United States.
Dental caries, a prevalent global health issue, results from complex bacterial interactions. In response to harmful stimuli, a desirable outcome for the tooth is the formation of tertiary dentin, a protective reparative process that generates new hard tissue. This reparative dentinogenesis is associated with significant inflammation, which triggers the recruitment and differentiation of dental pulp stem cells (DPSCs).
View Article and Find Full Text PDFClin Pract Cases Emerg Med
May 2025
Department of Emergency Medicine, Mayo Clinic, Jacksonville, Florida.
Introduction: A brain abscess is a localized collection of purulent infection within the brain parenchyma. It most often occurs due to contiguous spread from sinus, otogenic, and odontogenic infections; however, it can also develop from direct intracranial contact via trauma or surgery. Fusobacterium necrophorum, an obligate anaerobic, gram-negative bacillus, is part of the normal flora of the oral cavity.
View Article and Find Full Text PDFJ Prosthet Dent
May 2025
Associate Professor, Otolaryngology Unit, Department of Health Sciences, University of Milan, Milan, Italy.
Odontogenic sinusitis (ODS) refers to bacterial maxillary sinusitis caused by infectious maxillary dental pathology or dental procedures. ODS is the most common cause of unilateral sinusitis and a common cause of extrasinus infectious complications, including orbital and brain abscesses. While managing ODS has been highly successful, the greatest challenge can be recognizing and confirming the diagnosis.
View Article and Find Full Text PDFJ Neurol Sci
June 2025
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:
Polymicrobial brain abscess (PBA) is a complex infection caused by two or more pathogens and a life-threatening condition with diagnostic and therapeutic challenges. We retrospectively identified PBAs in 31 patients (24 males and 7 females) and examined their clinical, radiological and pathological characteristics. These characteristics of PBAs were compared with those of monomicrobial BAs (MBAs) in a previously reported cohort of 113 patients in our institution.
View Article and Find Full Text PDF