98%
921
2 minutes
20
The Brain Tumor Segmentation–Africa dataset is the first annotated publicly available brain imaging dataset from an African population; it contains three-dimensional MRI scans, retrospectively acquired from institutions in Nigeria, in 146 adult patients with preoperative brain tumors.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319694 | PMC |
http://dx.doi.org/10.1148/ryai.240528 | DOI Listing |
J Neurosurg Case Lessons
September 2025
Department of Neurosurgery, Kantonsspital Aarau, Switzerland.
Background: Meningioma en plaque (MEP) is a rare subtype of meningioma with a carpet-like growth pattern, often causing hyperostosis. Even rarer is the presentation of bilateral MEP posing diagnostic and therapeutic challenges. Management of MEP usually entails early complete resection.
View Article and Find Full Text PDFPLoS One
September 2025
Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence - ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHE
Prior studies from our laboratory have shown that cancer cells exposed to vitamin D3 exhibited reduced proliferation in breast cancer cells due to the upregulation of p53 and downregulation of cyclin-D1. Furthermore, in mice, our group has demonstrated that administration of 125 µg/kg of vitamin D3 retarded the growth of EAC tumors. But, it is unknown whether vitamin D3 exerts similar anti-cancer effects against cell lines representing carcinomas of the liver, colon and rectum, cervix, and brain.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
Multi-modal brain tumors segmentation is a critical step for diagnosing and monitoring brain-related disease. Many studies have developed models for this task, but two challenges remain, i.e.
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Neurosurgery, Qilu Hospital and Shandong Key Laboratory of Brain Health and Function Remodeling, Institute of Brain and Brain-Inspired Science, Jinan Microecological Biomedicine Shandong Laboratory, Cheeloo College of Medicine, Shandong University, 107 Wenhua Xi Road, Jinan, Shandong,
Innate immunity is crucial in orchestrating the brain immune response, however, glioblastoma multiforme (GBM) has evolved sophisticated mechanisms to evade innate immune surveillance, posing significant challenges for current immunotherapies. Here, a therapeutic strategy is reported that aims at reactivating innate immune responses in GBM via targeted induction of mitochondrial stress, thereby enhancing tumor immunogenicity. Specifically, innate immune-stimulating nanoparticles (INSTNA) are developed, encapsulating positively charged iridium-based complexes (Ir-mito) and small interfering RNA against Methylation-Controlled J protein (si-MCJ) to attenuate mitochondrial respiration.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
School of Biological and Health Systems Engineering (SBHSE), Arizona State University, Tempe, AZ, 85287, USA.
The prognosis of glioblastoma multiforme (GBM) remains dismal, despite standard treatment regimens. A key challenge in treating GBM is the persistence of glioma stem cells (GSCs) within the perivascular niche (PVN) - a protective tumor microenvironment (TME) that is often associated with inadequate drug penetration. Current preclinical models do not capture complexity of the human TME, particularly the vasculature and niche-specific interactions that drive GBM progression.
View Article and Find Full Text PDF